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| | ==Structure of ovine granulocyte-macrophage colony-stimulating factor== | | ==Structure of ovine granulocyte-macrophage colony-stimulating factor== |
| - | <StructureSection load='5d22' size='340' side='right' caption='[[5d22]], [[Resolution|resolution]] 1.99Å' scene=''> | + | <StructureSection load='5d22' size='340' side='right'caption='[[5d22]], [[Resolution|resolution]] 1.99Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5d22]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ovis_ammon_aries Ovis ammon aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D22 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D22 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5d22]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D22 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D22 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CSF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9940 Ovis ammon aries])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d22 OCA], [https://pdbe.org/5d22 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d22 RCSB], [https://www.ebi.ac.uk/pdbsum/5d22 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d22 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d22 OCA], [http://pdbe.org/5d22 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d22 RCSB], [http://www.ebi.ac.uk/pdbsum/5d22 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d22 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/CSF2_SHEEP CSF2_SHEEP]] Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | + | [https://www.uniprot.org/uniprot/CSF2_SHEEP CSF2_SHEEP] Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </div> | | </div> |
| | <div class="pdbe-citations 5d22" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 5d22" style="background-color:#fffaf0;"></div> |
| | + | |
| | + | ==See Also== |
| | + | *[[Colony-stimulating factor 3D structures|Colony-stimulating factor 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Ovis ammon aries]] | + | [[Category: Large Structures]] |
| - | [[Category: Felix, J]] | + | [[Category: Ovis aries]] |
| - | [[Category: Savvides, S N]] | + | [[Category: Felix J]] |
| - | [[Category: Cytokine]] | + | [[Category: Savvides SN]] |
| - | [[Category: Cytokine immunology]]
| + | |
| - | [[Category: Recombinant protein]]
| + | |
| - | [[Category: Signaling protein]]
| + | |
| Structural highlights
Function
CSF2_SHEEP Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
Publication Abstract from PubMed
Subversion of the host immune system by viruses is often mediated by molecular decoys that sequester host proteins pivotal to mounting effective immune responses. The widespread mammalian pathogen parapox Orf virus deploys GIF, a member of the poxvirus immune evasion superfamily, to antagonize GM-CSF (granulocyte macrophage colony-stimulating factor) and IL-2 (interleukin-2), two pleiotropic cytokines of the mammalian immune system. However, structural and mechanistic insights into the unprecedented functional duality of GIF have remained elusive. Here we reveal that GIF employs a dimeric binding platform that sequesters two copies of its target cytokines with high affinity and slow dissociation kinetics to yield distinct complexes featuring mutually exclusive interaction footprints. We illustrate how GIF serves as a competitive decoy receptor by leveraging binding hotspots underlying the cognate receptor interactions of GM-CSF and IL-2, without sharing any structural similarity with the cytokine receptors. Our findings contribute to the tracing of novel molecular mimicry mechanisms employed by pathogenic viruses.
Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.,Felix J, Kandiah E, De Munck S, Bloch Y, van Zundert GC, Pauwels K, Dansercoer A, Novanska K, Read RJ, Bonvin AM, Vergauwen B, Verstraete K, Gutsche I, Savvides SN Nat Commun. 2016 Nov 7;7:13228. doi: 10.1038/ncomms13228. PMID:27819269[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Felix J, Kandiah E, De Munck S, Bloch Y, van Zundert GC, Pauwels K, Dansercoer A, Novanska K, Read RJ, Bonvin AM, Vergauwen B, Verstraete K, Gutsche I, Savvides SN. Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF. Nat Commun. 2016 Nov 7;7:13228. doi: 10.1038/ncomms13228. PMID:27819269 doi:http://dx.doi.org/10.1038/ncomms13228
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