1lat

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[[Image:1lat.gif|left|200px]]
[[Image:1lat.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1lat |SIZE=350|CAPTION= <scene name='initialview01'>1lat</scene>, resolution 1.900&Aring;
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The line below this paragraph, containing "STRUCTURE_1lat", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= RAT GR AMINO ACIDS 440 TO 515 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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-->
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|DOMAIN=
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{{STRUCTURE_1lat| PDB=1lat | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lat OCA], [http://www.ebi.ac.uk/pdbsum/1lat PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lat RCSB]</span>
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}}
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'''GLUCOCORTICOID RECEPTOR MUTANT/DNA COMPLEX'''
'''GLUCOCORTICOID RECEPTOR MUTANT/DNA COMPLEX'''
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[[Category: Gewirth, D T.]]
[[Category: Gewirth, D T.]]
[[Category: Sigler, P B.]]
[[Category: Sigler, P B.]]
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[[Category: dna binding regulatory protein]]
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[[Category: Dna binding regulatory protein]]
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[[Category: glucocorticoid receptor]]
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[[Category: Glucocorticoid receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:43:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:00:27 2008''
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Revision as of 20:44, 2 May 2008

Image:1lat.gif

Template:STRUCTURE 1lat

GLUCOCORTICOID RECEPTOR MUTANT/DNA COMPLEX


Overview

Steroid receptors recognize bipartite targets composed of six base-pair half-sites. There are two canonical types of half-site which differ only in their central two base pairs. The crystal structure of an estrogen receptor-like DNA-binding domain bound to the wrong type of half-site (a glucocorticoid response element) reveals an interface that resembles the specific interfaces of the glucocorticoid receptor or estrogen receptor bound to their correct response elements. The underlying stereochemical defect that weakens the non-cognate interface is a difference in the helical geometry of the incorrect DNA half-site which prevents a side-chain contact and results in a gap which is filled by at least five additional fixed water sites, imposing a potential entropic burden on the stability of the interface.

About this Structure

1LAT is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The basis for half-site specificity explored through a non-cognate steroid receptor-DNA complex., Gewirth DT, Sigler PB, Nat Struct Biol. 1995 May;2(5):386-94. PMID:7664096 Page seeded by OCA on Fri May 2 23:43:59 2008

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OCA

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