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5da4

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Revision as of 10:27, 21 June 2023

Structure of a nanobody recognizing the fumarate transporter SLC26Dg

Structural highlights

5da4 is a 3 chain structure with sequence from Lama glama. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

The SLC26 family of membrane proteins combines a variety of functions within a conserved molecular scaffold. Its members, besides coupled anion transporters and channels, include the motor protein Prestin, which confers electromotility to cochlear outer hair cells. To gain insight into the architecture of this protein family, we characterized the structure and function of SLC26Dg, a facilitator of proton-coupled fumarate symport, from the bacterium Deinococcus geothermalis. Its modular structure combines a transmembrane unit and a cytoplasmic STAS domain. The membrane-inserted domain consists of two intertwined inverted repeats of seven transmembrane segments each and resembles the fold of the unrelated transporter UraA. It shows an inward-facing, ligand-free conformation with a potential substrate-binding site at the interface between two helix termini at the center of the membrane. This structure defines the common framework for the diverse functional behavior of the SLC26 family.

Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family.,Geertsma ER, Chang YN, Shaik FR, Neldner Y, Pardon E, Steyaert J, Dutzler R Nat Struct Mol Biol. 2015 Sep 14. doi: 10.1038/nsmb.3091. PMID:26367249^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Geertsma ER, Chang YN, Shaik FR, Neldner Y, Pardon E, Steyaert J, Dutzler R. Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family. Nat Struct Mol Biol. 2015 Sep 14. doi: 10.1038/nsmb.3091. PMID:26367249 doi:http://dx.doi.org/10.1038/nsmb.3091

1 Structural highlights
2 Publication Abstract from PubMed
3 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5da4"

@@ Line 3: / Line 3: @@
 <StructureSection load='5da4' size='340' side='right'caption='[[5da4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5da4]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DA4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DA4 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5da4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DA4 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5da4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5da4 OCA], [http://pdbe.org/5da4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5da4 RCSB], [http://www.ebi.ac.uk/pdbsum/5da4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5da4 ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5da4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5da4 OCA], [https://pdbe.org/5da4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5da4 RCSB], [https://www.ebi.ac.uk/pdbsum/5da4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5da4 ProSAT]</span></td></tr>
 </table>
 <div style="background-color:#fffaf0;">
@@ Line 19: / Line 19: @@
 __TOC__
 </StructureSection>
-[[Category: Camelus glama]]
+[[Category: Lama glama]]
 [[Category: Large Structures]]
-[[Category: Chang, Y]]
+[[Category: Chang Y]]
-[[Category: Dutzler, R]]
+[[Category: Dutzler R]]
-[[Category: Geertsma, E R]]
+[[Category: Geertsma ER]]
-[[Category: Shaik, F R]]
+[[Category: Shaik FR]]
-[[Category: Immune system]]
-[[Category: Membrane transport protein]]
-[[Category: Nanobody complex]]

5da4

From Proteopedia

Revision as of 10:27, 21 June 2023

Structure of a nanobody recognizing the fumarate transporter SLC26Dg

Structural highlights

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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