1lb2

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[[Image:1lb2.gif|left|200px]]
[[Image:1lb2.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1lb2 |SIZE=350|CAPTION= <scene name='initialview01'>1lb2</scene>, resolution 3.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1lb2", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CMP:ADENOSINE-3&#39;,5&#39;-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1lb2| PDB=1lb2 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lb2 OCA], [http://www.ebi.ac.uk/pdbsum/1lb2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lb2 RCSB]</span>
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}}
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'''Structure of the E. coli alpha C-terminal domain of RNA polymerase in complex with CAP and DNA'''
'''Structure of the E. coli alpha C-terminal domain of RNA polymerase in complex with CAP and DNA'''
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[[Category: Parkinson, G.]]
[[Category: Parkinson, G.]]
[[Category: Yang, H.]]
[[Category: Yang, H.]]
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[[Category: gene-regulatory]]
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[[Category: Gene-regulatory]]
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[[Category: protein-dna complex]]
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[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:44:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:00:32 2008''
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Revision as of 20:44, 2 May 2008

Image:1lb2.gif

Template:STRUCTURE 1lb2

Structure of the E. coli alpha C-terminal domain of RNA polymerase in complex with CAP and DNA


Overview

The Escherichia coli catabolite activator protein (CAP) activates transcription at P(lac), P(gal), and other promoters through interactions with the RNA polymerase alpha subunit carboxyl-terminal domain (alphaCTD). We determined the crystal structure of the CAP-alphaCTD-DNA complex at a resolution of 3.1 angstroms. CAP makes direct protein-protein interactions with alphaCTD, and alphaCTD makes direct protein-DNA interactions with the DNA segment adjacent to the DNA site for CAP. There are no large-scale conformational changes in CAP and alphaCTD, and the interface between CAP and alphaCTD is small. These findings are consistent with the proposal that activation involves a simple "recruitment" mechanism.

About this Structure

1LB2 is a Protein complex structure of sequences from Escherichia coli. The following page contains interesting information on the relation of 1LB2 with [Catabolite Activator Protein]. Full crystallographic information is available from OCA.

Reference

Structural basis of transcription activation: the CAP-alpha CTD-DNA complex., Benoff B, Yang H, Lawson CL, Parkinson G, Liu J, Blatter E, Ebright YW, Berman HM, Ebright RH, Science. 2002 Aug 30;297(5586):1562-6. PMID:12202833 Page seeded by OCA on Fri May 2 23:44:23 2008

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OCA

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