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User:Marcella Maringolo/Sandbox 1
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(Difference between revisions)
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== Function and Structural highlights == | == Function and Structural highlights == | ||
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| - | == Relevance == | ||
Here we show the <scene name='97/973093/Human_nf-y/2'>Human NF-Y</scene> molecule structure while binding to the DNA, with each subunit represented in a different color: NF-YA in blue, NF-YB in green and NF-YC in pink, while the DNA is represented in grey. Here is its <scene name='97/973093/Human_nf-y/9'>Backbone</scene> and its <scene name='97/973093/Secondary_structure/1'>Secondary structure</scene> with alpha-helixes colored in pink, and beta-sheets colored in yellow. Using the <scene name='97/973093/Cartoon/1'>cartoon</scene> representation we can see the secondary structures in each subunit. | Here we show the <scene name='97/973093/Human_nf-y/2'>Human NF-Y</scene> molecule structure while binding to the DNA, with each subunit represented in a different color: NF-YA in blue, NF-YB in green and NF-YC in pink, while the DNA is represented in grey. Here is its <scene name='97/973093/Human_nf-y/9'>Backbone</scene> and its <scene name='97/973093/Secondary_structure/1'>Secondary structure</scene> with alpha-helixes colored in pink, and beta-sheets colored in yellow. Using the <scene name='97/973093/Cartoon/1'>cartoon</scene> representation we can see the secondary structures in each subunit. | ||
| + | The NF-Y binding to the DNA depends initially on the hetrodimerization of NF-YB and NF-YC subunits, which associate and then allow NF-YA to associate with the complex, which is now ready for binding to the CCAAT sequence in the DNA. NF-YA has a specific C-terminal domain responsible for CCAAT recognition, and the binding is shown in the image below. | ||
[[Image:NF-YA.jpg]] | [[Image:NF-YA.jpg]] | ||
| + | Although NF-YA is responsible for DNA site recognition, all of the 3 NF-Y subunits can contact DNA after CCAAT binding, and the contact regions are shown in the image below. | ||
[[Image:NF-Y DNA.jpg]] | [[Image:NF-Y DNA.jpg]] | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 15:47, 21 June 2023
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