1lbe

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[[Image:1lbe.gif|left|200px]]
[[Image:1lbe.gif|left|200px]]
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{{Structure
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|PDB= 1lbe |SIZE=350|CAPTION= <scene name='initialview01'>1lbe</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1lbe", creates the "Structure Box" on the page.
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|SITE=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span>
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{{STRUCTURE_1lbe| PDB=1lbe | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lbe OCA], [http://www.ebi.ac.uk/pdbsum/1lbe PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lbe RCSB]</span>
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'''APLYSIA ADP RIBOSYL CYCLASE'''
'''APLYSIA ADP RIBOSYL CYCLASE'''
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Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38., Prasad GS, McRee DE, Stura EA, Levitt DG, Lee HC, Stout CD, Nat Struct Biol. 1996 Nov;3(11):957-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8901875 8901875]
Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38., Prasad GS, McRee DE, Stura EA, Levitt DG, Lee HC, Stout CD, Nat Struct Biol. 1996 Nov;3(11):957-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8901875 8901875]
[[Category: Aplysia californica]]
[[Category: Aplysia californica]]
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[[Category: NAD(+) nucleosidase]]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Lee, H C.]]
[[Category: Lee, H C.]]
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[[Category: Stout, C D.]]
[[Category: Stout, C D.]]
[[Category: Stura, E A.]]
[[Category: Stura, E A.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: nad(+) nucleosidase]]
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[[Category: Nadase]]
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[[Category: nadase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:45:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:00:43 2008''
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Revision as of 20:45, 2 May 2008

Image:1lbe.gif

Template:STRUCTURE 1lbe

APLYSIA ADP RIBOSYL CYCLASE


Overview

ADP ribosyl cyclase synthesizes the novel secondary messenger cyclic ADP ribose (cADPR) utilizing NAD as a substrate. The enzyme shares extensive sequence similarity with two lymphocyte antigens, CD38 and BST-1, which hydrolyse as well as synthesize cADPR. The crystal structure provides a model for these cell surface enzymes. Cyclase contains two spatially separated pockets composed of sequence conserved residues, suggesting that the cyclization reaction may entail use of distinct sites. The enzyme dimer encloses a cavity which may entrap the intermediate, ADP ribose.

About this Structure

1LBE is a Single protein structure of sequence from Aplysia californica. Full crystallographic information is available from OCA.

Reference

Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38., Prasad GS, McRee DE, Stura EA, Levitt DG, Lee HC, Stout CD, Nat Struct Biol. 1996 Nov;3(11):957-64. PMID:8901875 Page seeded by OCA on Fri May 2 23:45:16 2008

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