User:Davi de Souza/Sandbox 1
From Proteopedia
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<StructureSection load='5jzt' size='360' side='right' caption='Oligomer structure of Aerolysin' scene=''> | <StructureSection load='5jzt' size='360' side='right' caption='Oligomer structure of Aerolysin' scene=''> | ||
== Structure == | == Structure == | ||
| - | <scene name='97/973994/Proaerolysin/ | + | <scene name='97/973994/Proaerolysin/5'>Proaerolysin</scene> is a protein that consists of <scene name='97/973994/Proaerolysin/1'>4 domains</scene>: |
Domains 1 and 2 are responsible for binding to N-glycosylated phosphatidylinositol (GPI) proteins, which are present in the membranes of eukaryotic cells. Domain 1 binds to specific sugar modifications found on the GPI receptor, while domain 2 directly binds to the glycan core located in the central portion of GPI proteins. Therefore, both domain 1 and domain 2 are involved in anchoring the aerolysin proprotein to the target cell membrane. | Domains 1 and 2 are responsible for binding to N-glycosylated phosphatidylinositol (GPI) proteins, which are present in the membranes of eukaryotic cells. Domain 1 binds to specific sugar modifications found on the GPI receptor, while domain 2 directly binds to the glycan core located in the central portion of GPI proteins. Therefore, both domain 1 and domain 2 are involved in anchoring the aerolysin proprotein to the target cell membrane. | ||
Revision as of 19:36, 25 June 2023
Abstract
Aerolysin is a protein synthesized by some species of bacteria belonging to the genus Aeromonas, such as Aeromonas hydrophila. The exact function of Aerolysin may vary among different species and strains of Aeromonas. However, it is evident that it is the main macromolecule responsible for the pathogenicity of Aeromonas hydrophila, being associated with diarrheal diseases and deep wound infections [1]. About the structure of the protein, it is known that the aerolysin can be found in the soluble form, which is the monomere unactivated called proaerolysin and in the oligomere form, unsoluble and containing the activated forms of the monomere.
Function
Aerolysin plays several roles in the pathogenicity of Aeromonas spp. One of its main functions is its ability to promote lysis (rupture) of host cells, such as epithelial cells and immune cells. Aerolysin exhibits cytotoxic activity, causing damage to the cell membranes of host cells, which can lead to cell death and contribute to the bacterium's pathogenicity. Furthermore, aerolysin may be involved in the invasion and dissemination of the bacterium within the host. It can assist in tissue degradation, facilitating the bacterium's invasion into different organs and tissues of the host. It is important to note that the exact function of aerolysin may vary among different species and strains of Aeromonas. Additionally, there are other proteins and virulence factors produced by Aeromonas spp. that also play important roles in the pathogenicity of these bacteria.
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References
- ↑ Altwegg M, Geiss HK. Aeromonas as a human pathogen. Crit Rev Microbiol. 1989;16(4):253-86. PMID:2649316 doi:10.3109/10408418909105478
