1kxg

From Proteopedia

---

Revision as of 15:49, 12 November 2007

proteopedia linkproteopedia link

spinqualitylabelsall models 1kxg, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.

Overview

B lymphocyte stimulator (BLyS), a member of the tumor necrosis factor, (TNF) superfamily, is a cytokine that induces B-cell proliferation and, immunoglobulin secretion. We have determined the three-dimensional, structure of BLyS to 2.0 A resolution and identified receptor recognition, segments using limited proteolysis coupled with mass spectrometry. Similar, to other structurally determined TNF-like ligands, the BLyS monomer is a, beta-sandwich and oligomerizes to form a homotrimer. The receptor-binding, region in BLyS is a deeper, more pronounced groove than in other, cytokines. The conserved elements on the 'floor' of this groove allow for, cytokine recognition of several structurally related receptors, whereas, variations on the 'walls' and outer rims of the groove confer receptor, specificity.

About this Structure

1KXG is a Single protein structure of sequence from Homo sapiens with MG, CIT and DIO as ligands. Full crystallographic information is available from OCA.

Reference

Structural basis of BLyS receptor recognition., Oren DA, Li Y, Volovik Y, Morris TS, Dharia C, Das K, Galperina O, Gentz R, Arnold E, Nat Struct Biol. 2002 Apr;9(4):288-92. PMID:11862220

Page seeded by OCA on Mon Nov 12 17:55:42 2007