1kxu
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(New page: 200px<br /> <applet load="1kxu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kxu, resolution 2.60Å" /> '''CYCLIN H, A POSITIV...)
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Revision as of 15:49, 12 November 2007
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CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE
Overview
Cyclin-dependent kinases (CDKs), which play a key role in cell cycle, control, are activated by the CDK activating kinase (CAK), which activates, cyclin-bound CDKs by phosphorylation at a specific threonine residue., Vertebrate CAK contains two key components: a kinase subunit with homology, to its substrate CDKs and a regulatory subunit with homology to cyclins., We have determined the X-ray crystal structure of the regulatory subunit, of CAK, cyclin H, at 2.6 A resolution. Cyclin H contains two alpha-helical, core domains with a fold similar to that of cyclin A, a regulatory subunit, of CAK substrate CDK2, and of TFIIB, a transcription factor. Outside of, the core domains, the N- and C-terminal regions of the three structures, are completely different. The conformational differences between cyclin H, and A structures may reflect functional differences between the two, cyclins.
About this Structure
1KXU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase., Kim KK, Chamberlin HM, Morgan DO, Kim SH, Nat Struct Biol. 1996 Oct;3(10):849-55. PMID:8836101
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