7y7l

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'''Unreleased structure'''
 
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The entry 7y7l is ON HOLD until Paper Publication
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==Solution structure of zinc finger domain 2 of human ZFAND1==
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<StructureSection load='7y7l' size='340' side='right'caption='[[7y7l]]' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7y7l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y7L FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y7l OCA], [https://pdbe.org/7y7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y7l RCSB], [https://www.ebi.ac.uk/pdbsum/7y7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y7l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ZFAN1_HUMAN ZFAN1_HUMAN] Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress (PubMed:29804830). Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome (PubMed:29804830). This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy (PubMed:29804830).<ref>PMID:29804830</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chang CF]]
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[[Category: Fang PJ]]
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[[Category: Hsu STD]]
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[[Category: Ko KT]]
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[[Category: Lai CH]]

Revision as of 21:13, 28 June 2023

Solution structure of zinc finger domain 2 of human ZFAND1

PDB ID 7y7l

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OCA

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