8byl

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'''Unreleased structure'''
 
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The entry 8byl is ON HOLD until Paper Publication
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==Cryo-EM structure of SKP1-SKP2-CKS1 from the SCFSKP2 E3 ligase complex==
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<StructureSection load='8byl' size='340' side='right'caption='[[8byl]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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Authors: Rowland, R.J., Salamina, M., Endicott, J.A., Noble, M.E.M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8byl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BYL FirstGlance]. <br>
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Description: Cryo-EM structure of SKP1-SKP2-CKS1 from the SCFSKP2 E3 ligase complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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[[Category: Endicott, J.A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8byl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8byl OCA], [https://pdbe.org/8byl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8byl RCSB], [https://www.ebi.ac.uk/pdbsum/8byl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8byl ProSAT]</span></td></tr>
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[[Category: Noble, M.E.M]]
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</table>
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[[Category: Rowland, R.J]]
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== Disease ==
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[[Category: Salamina, M]]
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[https://www.uniprot.org/uniprot/CDN1B_HUMAN CDN1B_HUMAN] Defects in CDKN1B are the cause of multiple endocrine neoplasia type 4 (MEN4) [MIM:[https://omim.org/entry/610755 610755]. Multiple endocrine neoplasia (MEN) syndromes are inherited cancer syndromes of the thyroid. MEN4 is a MEN-like syndrome with a phenotypic overlap of both MEN1 and MEN2.<ref>PMID:17030811</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CDN1B_HUMAN CDN1B_HUMAN] Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.<ref>PMID:10831586</ref> <ref>PMID:12244301</ref> <ref>PMID:16782892</ref> <ref>PMID:19075005</ref> <ref>PMID:17254966</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Endicott JA]]
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[[Category: Noble MEM]]
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[[Category: Rowland RJ]]
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[[Category: Salamina M]]

Revision as of 21:14, 28 June 2023

Cryo-EM structure of SKP1-SKP2-CKS1 from the SCFSKP2 E3 ligase complex

PDB ID 8byl

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