8pdh

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m (Protected "8pdh" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8pdh is ON HOLD
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==The phosphatase and C2 domains of SHIP1 with covalent Z1742148362==
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<StructureSection load='8pdh' size='340' side='right'caption='[[8pdh]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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Authors: Bradshaw, W.J., Moreira, T., Pascoa, T.C., Bountra, C., Chalk, R., von Delft, F., Brennan, P.E., Gileadi, O.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8pdh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PDH FirstGlance]. <br>
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Description: The phosphatase and C2 domains of SHIP1 with covalent Z1742148362
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=YBU:(5-phenyl-1,3,4-oxadiazol-2-yl)methanimine'>YBU</scene></td></tr>
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[[Category: Moreira, T]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pdh OCA], [https://pdbe.org/8pdh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pdh RCSB], [https://www.ebi.ac.uk/pdbsum/8pdh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pdh ProSAT]</span></td></tr>
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[[Category: Bradshaw, W.J]]
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</table>
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[[Category: Bountra, C]]
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== Function ==
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[[Category: Chalk, R]]
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[https://www.uniprot.org/uniprot/SHIP1_HUMAN SHIP1_HUMAN] Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.<ref>PMID:12421919</ref> <ref>PMID:16682172</ref>
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[[Category: Von Delft, F]]
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== References ==
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[[Category: Pascoa, T.C]]
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<references/>
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[[Category: Gileadi, O]]
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__TOC__
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[[Category: Brennan, P.E]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bountra C]]
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[[Category: Bradshaw WJ]]
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[[Category: Brennan PE]]
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[[Category: Chalk R]]
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[[Category: Gileadi O]]
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[[Category: Moreira T]]
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[[Category: Pascoa TC]]
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[[Category: Von Delft F]]

Revision as of 21:21, 28 June 2023

The phosphatase and C2 domains of SHIP1 with covalent Z1742148362

PDB ID 8pdh

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