1lcy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1lcy.gif|left|200px]]
[[Image:1lcy.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1lcy |SIZE=350|CAPTION= <scene name='initialview01'>1lcy</scene>, resolution 2.00&Aring;
+
The line below this paragraph, containing "STRUCTURE_1lcy", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1lcy| PDB=1lcy | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lcy OCA], [http://www.ebi.ac.uk/pdbsum/1lcy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lcy RCSB]</span>
+
-
}}
+
'''Crystal Structure of the Mitochondrial Serine Protease HtrA2'''
'''Crystal Structure of the Mitochondrial Serine Protease HtrA2'''
Line 33: Line 30:
[[Category: Wu, J W.]]
[[Category: Wu, J W.]]
[[Category: Zhang, Z.]]
[[Category: Zhang, Z.]]
-
[[Category: apoptosis]]
+
[[Category: Apoptosis]]
-
[[Category: caspase activation]]
+
[[Category: Caspase activation]]
-
[[Category: iap-binding]]
+
[[Category: Iap-binding]]
-
[[Category: pdz domain]]
+
[[Category: Pdz domain]]
-
[[Category: serine protease]]
+
[[Category: Serine protease]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:47:59 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:01:13 2008''
+

Revision as of 20:48, 2 May 2008

Image:1lcy.gif

Template:STRUCTURE 1lcy

Crystal Structure of the Mitochondrial Serine Protease HtrA2


Overview

HtrA2/Omi, a mitochondrial serine protease in mammals, is important in programmed cell death. However, the underlining mechanism of HtrA2/Omi-mediated apoptosis remains unclear. Analogous to the bacterial homolog HtrA (DegP), the mature HtrA2 protein contains a central serine protease domain and a C-terminal PDZ domain. The 2.0 A crystal structure of HtrA2/Omi reveals the formation of a pyramid-shaped homotrimer mediated exclusively by the serine protease domains. The peptide-binding pocket of the PDZ domain is buried in the intimate interface between the PDZ and the protease domains. Mutational analysis reveals that the monomeric HtrA2/Omi mutants are unable to induce cell death and are deficient in protease activity. The PDZ domain modulates HtrA2/Omi-mediated cell death activity by regulating its serine protease activity. These structural and biochemical observations provide an important framework for deciphering the mechanisms of HtrA2/Omi-mediated apoptosis.

About this Structure

1LCY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi., Li W, Srinivasula SM, Chai J, Li P, Wu JW, Zhang Z, Alnemri ES, Shi Y, Nat Struct Biol. 2002 Jun;9(6):436-41. PMID:11967569 Page seeded by OCA on Fri May 2 23:47:59 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1lcy"
Personal tools