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5dgs

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Current revision (21:41, 28 June 2023) (edit) (undo)
 
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==Crystal structure of human FPPS in complex with the monophosphonate compound 15==
==Crystal structure of human FPPS in complex with the monophosphonate compound 15==
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<StructureSection load='5dgs' size='340' side='right' caption='[[5dgs]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
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<StructureSection load='5dgs' size='340' side='right'caption='[[5dgs]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5dgs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DGS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DGS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5dgs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DGS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5A7:{(E)-2-[6-(ACETYLAMINO)-8-(NAPHTHALEN-1-YL)QUINOLIN-2-YL]ETHENYL}PHOSPHONIC+ACID'>5A7</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.62&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dgm|5dgm]], [[5dgn|5dgn]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5A7:{(E)-2-[6-(ACETYLAMINO)-8-(NAPHTHALEN-1-YL)QUINOLIN-2-YL]ETHENYL}PHOSPHONIC+ACID'>5A7</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dgs OCA], [https://pdbe.org/5dgs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dgs RCSB], [https://www.ebi.ac.uk/pdbsum/5dgs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dgs ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dgs OCA], [http://pdbe.org/5dgs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dgs RCSB], [http://www.ebi.ac.uk/pdbsum/5dgs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dgs ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5dgs" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5dgs" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Bourgier, E]]
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[[Category: Large Structures]]
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[[Category: Lehmann, S]]
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[[Category: Bourgier E]]
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[[Category: Rondeau, J M]]
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[[Category: Lehmann S]]
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[[Category: Cholesterol biosynthesis]]
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[[Category: Rondeau JM]]
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[[Category: Isoprene biosynthesis]]
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[[Category: Transferase]]
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Current revision

Crystal structure of human FPPS in complex with the monophosphonate compound 15

PDB ID 5dgs

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