5dlm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (21:48, 28 June 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='5dlm' size='340' side='right'caption='[[5dlm]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='5dlm' size='340' side='right'caption='[[5dlm]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5dlm]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DLM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DLM FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5dlm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DLM FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5dlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dlm OCA], [http://pdbe.org/5dlm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dlm RCSB], [http://www.ebi.ac.uk/pdbsum/5dlm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dlm ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dlm OCA], [https://pdbe.org/5dlm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dlm RCSB], [https://www.ebi.ac.uk/pdbsum/5dlm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dlm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/M2_I45A0 M2_I45A0]] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).
+
[https://www.uniprot.org/uniprot/M2_I34A1 M2_I34A1] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.[HAMAP-Rule:MF_04069]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 25: Line 26:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Influenza A virus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Cho, K J]]
+
[[Category: Cho KJ]]
-
[[Category: Deng, L]]
+
[[Category: Deng L]]
-
[[Category: Fiers, W]]
+
[[Category: Fiers W]]
-
[[Category: Moonens, K]]
+
[[Category: Moonens K]]
-
[[Category: Remaut, H]]
+
[[Category: Remaut H]]
-
[[Category: Saelens, X]]
+
[[Category: Saelens X]]
-
[[Category: Schepens, B]]
+
[[Category: Schepens B]]
-
[[Category: Antibody]]
+
-
[[Category: Complex]]
+
-
[[Category: Extracellular domain]]
+
-
[[Category: Immune system]]
+

Current revision

Complex of Influenza M2e and Antibody

PDB ID 5dlm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5dlm"
Personal tools