Mitogen-activated protein kinase kinase kinase
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | [[Mitogen-activated protein kinase kinase kinase]] (MAP3K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP3K is part of the MAPK cascade which consists also of [[Mitogen-activated protein kinase|MAPK]] and [[Mitogen-activated protein kinase kinase|MAP2K]] which are activated by phosphorylation. MAP3K activates [[Mitogen-activated protein kinase kinase|MAP2K]]<ref>PMID:9006902</ref>. | + | [[Mitogen-activated protein kinase kinase kinase]] or '''DLK''' (MAP3K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP3K is part of the MAPK cascade which consists also of [[Mitogen-activated protein kinase|MAPK]] and [[Mitogen-activated protein kinase kinase|MAP2K]] which are activated by phosphorylation. MAP3K activates [[Mitogen-activated protein kinase kinase|MAP2K]]<ref>PMID:9006902</ref>. |
== Disease == | == Disease == | ||
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**[[2pph]] - hMAP3K3 PB1 domain - NMR | **[[2pph]] - hMAP3K3 PB1 domain - NMR | ||
| - | *MAP3K5 | + | *MAP3K5 (Ask1; Apoptosis signal-regulating kinase 1) |
**[[2clq]] – hMAP3K5<br /> | **[[2clq]] – hMAP3K5<br /> | ||
| - | **[[6oyt]], [[6vre]], [[6xih]] - hMAP3K5 + inhibitor<br /> | + | **[[6oyt]], [[6vre]], [[6xih]], [[7mu7]] - hMAP3K5 + inhibitor<br /> |
**[[4bf2]], [[4bhn]], [[4bib]], [[4bic]], [[4bid]], [[4bie]], [[6e2m]], [[6e2n]], [[6e2o]], [[6oyw]] - hMAP3K5 (mutant) + inhibitor<br /> | **[[4bf2]], [[4bhn]], [[4bib]], [[4bic]], [[4bid]], [[4bie]], [[6e2m]], [[6e2n]], [[6e2o]], [[6oyw]] - hMAP3K5 (mutant) + inhibitor<br /> | ||
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**[[2eva]] – hMAP3K7/MAP3K7-interacting protein 1<br /> | **[[2eva]] – hMAP3K7/MAP3K7-interacting protein 1<br /> | ||
| - | **[[ | + | **[[2y1y]], [[4gs4]], [[4l3p]], [[4l52]], [[4l53]], [[4o91]], [[5gjd]], [[5gjf]], [[5gjg]], [[5e7r]], [[5jga]], [[5jgb]], [[5jgd]], [[7nth]] - hMAP3K7/MAP3K7-interacting protein 1 + inhibitor<br /> |
*MAP3K9 | *MAP3K9 | ||
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**[[2rf0]] - hMAP3K10 SH3 domain - NMR | **[[2rf0]] - hMAP3K10 SH3 domain - NMR | ||
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| + | *MAP3K12 | ||
| + | |||
| + | **[[8deg]] - hMAP3K12 + inhibitor<br /> | ||
*MAP3K11 | *MAP3K11 | ||
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**[[5ceo]] - hMAP3K12 + inhibitor<br /> | **[[5ceo]] - hMAP3K12 + inhibitor<br /> | ||
| - | *MAP3K14 kinase domain 343-686 | + | *MAP3K14 kinase domain 343-686 (NIK) |
**[[4dn5]] - hMAP3K14 (mutant) + ATP-γ-S<br /> | **[[4dn5]] - hMAP3K14 (mutant) + ATP-γ-S<br /> | ||
**[[4idt]], [[4idv]], [[6wpp]], [[6z1q]], [[6z1t]] - hMAP3K14 + inhibitor<br /> | **[[4idt]], [[4idv]], [[6wpp]], [[6z1q]], [[6z1t]] - hMAP3K14 + inhibitor<br /> | ||
| - | **[[6g4y]], [[6g4z]], [[6myn]] - mMAP3K14 + inhibitor<br /> | + | **[[6g4y]], [[6g4z]], [[6myn]], [[7szr]] - mMAP3K14 + inhibitor<br /> |
*MAP3K15 | *MAP3K15 | ||
Revision as of 07:52, 2 July 2023
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3D Structures of Mitogen-activated protein kinase kinase kinase
Updated on 02-July-2023
References
- ↑ Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative. J Biol Chem. 1997 Jan 31;272(5):2668-74. PMID:9006902
- ↑ Santen RJ, Song RX, McPherson R, Kumar R, Adam L, Jeng MH, Yue W. The role of mitogen-activated protein (MAP) kinase in breast cancer. J Steroid Biochem Mol Biol. 2002 Feb;80(2):239-56. PMID:11897507
