1lev

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[[Image:1lev.jpg|left|200px]]
[[Image:1lev.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1lev |SIZE=350|CAPTION= <scene name='initialview01'>1lev</scene>, resolution 2.15&Aring;
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The line below this paragraph, containing "STRUCTURE_1lev", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CLI:3-(2-CARBOXY-ETHYL)-4,6-DICHLORO-1H-INDOLE-2-CARBOXYLIC+ACID'>CLI</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1lev| PDB=1lev | SCENE= }}
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|RELATEDENTRY=[[1fbp|1FBP]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lev OCA], [http://www.ebi.ac.uk/pdbsum/1lev PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lev RCSB]</span>
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}}
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'''PORCINE KIDNEY FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH AN AMP-SITE INHIBITOR'''
'''PORCINE KIDNEY FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH AN AMP-SITE INHIBITOR'''
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[[Category: Wang, I K.]]
[[Category: Wang, I K.]]
[[Category: Wright, S W.]]
[[Category: Wright, S W.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:51:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:01:55 2008''
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Revision as of 20:51, 2 May 2008

Image:1lev.jpg

Template:STRUCTURE 1lev

PORCINE KIDNEY FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH AN AMP-SITE INHIBITOR


Overview

3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid (MDL-29951), an antagonist of the glycine site of the NMDA receptor, has been found to be an allosteric inhibitor of the enzyme fructose 1,6-bisphosphatase. The compound binds at the AMP regulatory site by X-ray crystallography. This represents a new approach to inhibition of fructose 1,6-bisphosphatase and serves as a lead for further drug design.

About this Structure

1LEV is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site., Wright SW, Carlo AA, Danley DE, Hageman DL, Karam GA, Mansour MN, McClure LD, Pandit J, Schulte GK, Treadway JL, Wang IK, Bauer PH, Bioorg Med Chem Lett. 2003 Jun 16;13(12):2055-8. PMID:12781194 Page seeded by OCA on Fri May 2 23:51:15 2008

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OCA

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