7y35

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'''Unreleased structure'''
 
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The entry 7y35 is ON HOLD until Paper Publication
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==Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex==
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<StructureSection load='7y35' size='340' side='right'caption='[[7y35]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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Authors: Zhai, X., Mao, C., Shen, Q., Zang, S., Shen, D., Zhang, H., Chen, Z., Wang, G., Zhang, C., Zhang, Y., Liu, Z.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7y35]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y35 FirstGlance]. <br>
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Description: Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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[[Category: Zhang, Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y35 OCA], [https://pdbe.org/7y35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y35 RCSB], [https://www.ebi.ac.uk/pdbsum/7y35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y35 ProSAT]</span></td></tr>
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[[Category: Zhang, H]]
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</table>
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[[Category: Liu, Z]]
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== Disease ==
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[[Category: Zhai, X]]
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[https://www.uniprot.org/uniprot/PTH1R_HUMAN PTH1R_HUMAN] Blomstrand lethal chondrodysplasia;Dental ankylosis;Eiken syndrome;Metaphyseal chondrodysplasia, Jansen type;Enchondromatosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease may be caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[[Category: Wang, G]]
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== Function ==
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[[Category: Zang, S]]
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[https://www.uniprot.org/uniprot/PTH1R_HUMAN PTH1R_HUMAN] This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.<ref>PMID:18611381</ref> <ref>PMID:20172855</ref>
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[[Category: Chen, Z]]
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== References ==
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[[Category: Shen, D]]
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<references/>
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[[Category: Zhang, C]]
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__TOC__
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[[Category: Shen, Q]]
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</StructureSection>
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[[Category: Mao, C]]
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[[Category: Bos taurus]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Rattus norvegicus]]
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[[Category: Synthetic construct]]
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[[Category: Chen Z]]
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[[Category: Liu Z]]
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[[Category: Mao C]]
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[[Category: Shen D]]
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[[Category: Shen Q]]
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[[Category: Wang G]]
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[[Category: Zang S]]
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[[Category: Zhai X]]
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[[Category: Zhang C]]
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[[Category: Zhang H]]
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[[Category: Zhang Y]]

Revision as of 05:37, 5 July 2023

Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex

PDB ID 7y35

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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