8de4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Native serotonin transporter in complex with 15B8 Fab in the presence of methamphetamine== | |
| - | + | <StructureSection load='8de4' size='340' side='right'caption='[[8de4]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8de4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DE4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B40:(2S)-N-METHYL-1-PHENYLPROPAN-2-AMINE'>B40</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8de4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8de4 OCA], [https://pdbe.org/8de4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8de4 RCSB], [https://www.ebi.ac.uk/pdbsum/8de4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8de4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A4X1TV69_PIG A0A4X1TV69_PIG] Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.[ARBA:ARBA00025296] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Sus scrofa]] | ||
| + | [[Category: Gouaux E]] | ||
| + | [[Category: Yang D]] | ||
Revision as of 05:41, 5 July 2023
Native serotonin transporter in complex with 15B8 Fab in the presence of methamphetamine
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