1lf9

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[[Image:1lf9.gif|left|200px]]
[[Image:1lf9.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1lf9 |SIZE=350|CAPTION= <scene name='initialview01'>1lf9</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1lf9", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACR:ACARBOSE'>ACR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucan_1,4-alpha-glucosidase Glucan 1,4-alpha-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.3 3.2.1.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1lf9| PDB=1lf9 | SCENE= }}
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|RELATEDENTRY=[[1ayx|1AYX]], [[3gly|3GLY]], [[1lf6|1LF6]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lf9 OCA], [http://www.ebi.ac.uk/pdbsum/1lf9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lf9 RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF BACTERIAL GLUCOAMYLASE COMPLEXED WITH ACARBOSE'''
'''CRYSTAL STRUCTURE OF BACTERIAL GLUCOAMYLASE COMPLEXED WITH ACARBOSE'''
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[[Category: Honzatko, R B.]]
[[Category: Honzatko, R B.]]
[[Category: Reilly, P J.]]
[[Category: Reilly, P J.]]
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[[Category: (alpha/alpha) barrel]]
 
[[Category: 6 alpha-helical hairpin torroid]]
[[Category: 6 alpha-helical hairpin torroid]]
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[[Category: acarbose]]
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[[Category: Acarbose]]
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[[Category: carbohydrase family gh15]]
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[[Category: Carbohydrase family gh15]]
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[[Category: super beta sandwich]]
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[[Category: Super beta sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:52:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:02:06 2008''
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Revision as of 20:52, 2 May 2008

Image:1lf9.gif

Template:STRUCTURE 1lf9

CRYSTAL STRUCTURE OF BACTERIAL GLUCOAMYLASE COMPLEXED WITH ACARBOSE


Overview

The first crystal structures of a two-domain, prokaryotic glucoamylase were determined to high resolution from the clostridial species Thermoanaerobacterium thermosaccharolyticum with and without acarbose. The N-terminal domain has 18 antiparallel strands arranged in beta-sheets of a super-beta-sandwich. The C-terminal domain is an (alpha/alpha)(6) barrel, lacking the peripheral subdomain of eukaryotic glucoamylases. Interdomain contacts are common to all prokaryotic Family GH15 proteins. Domains similar to those of prokaryotic glucoamylases in maltose phosphorylases (Family GH65) and glycoaminoglycan lyases (Family PL8) suggest evolution from a common ancestor. Eukaryotic glucoamylases may have evolved from prokaryotic glucoamylases by the substitution of the N-terminal domain with the peripheral subdomain and by the addition of a starch-binding domain.

About this Structure

1LF9 is a Single protein structure of sequence from Thermoanaerobacterium thermosaccharolyticum. Full crystallographic information is available from OCA.

Reference

Crystal structure and evolution of a prokaryotic glucoamylase., Aleshin AE, Feng PH, Honzatko RB, Reilly PJ, J Mol Biol. 2003 Mar 14;327(1):61-73. PMID:12614608 Page seeded by OCA on Fri May 2 23:52:08 2008

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