8j0k

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:46, 5 July 2023) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8j0k is ON HOLD until Paper Publication
+
==Crystal structure of human TFAP2A in complex with DNA==
-
 
+
<StructureSection load='8j0k' size='340' side='right'caption='[[8j0k]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
Authors: Liu, K., Xiao, Y.Q., Li, W.F., Min, J.R.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8j0k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J0K FirstGlance]. <br>
-
Description: Crystal structure of human TFAP2A in complex with DNA
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG3:GUANIDINE-3-PROPANOL'>PG3</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-
[[Category: Xiao, Y.Q]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j0k OCA], [https://pdbe.org/8j0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j0k RCSB], [https://www.ebi.ac.uk/pdbsum/8j0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j0k ProSAT]</span></td></tr>
-
[[Category: Min, J.R]]
+
</table>
-
[[Category: Li, W.F]]
+
== Disease ==
-
[[Category: Liu, K]]
+
[https://www.uniprot.org/uniprot/AP2A_HUMAN AP2A_HUMAN] Branchio-oculo-facial syndrome. The disease is caused by variants affecting the gene represented in this entry.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/AP2A_HUMAN AP2A_HUMAN] Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.<ref>PMID:11694877</ref> <ref>PMID:12586840</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Synthetic construct]]
 +
[[Category: Li WF]]
 +
[[Category: Liu K]]
 +
[[Category: Min JR]]
 +
[[Category: Xiao YQ]]

Current revision

Crystal structure of human TFAP2A in complex with DNA

PDB ID 8j0k

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8j0k"
Personal tools