8shj

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Current revision (05:48, 5 July 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8shj is ON HOLD
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==Crystal structure of the WD-repeat domain of human WDR91 in complex with MR45279==
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<StructureSection load='8shj' size='340' side='right'caption='[[8shj]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
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Authors: Ahmad, H., Zeng, H., Dong, A., Li, Y., Hutchinson, A., Seitova, A., Xu, J., Feng, J.W., Brown, P.J., Ackloo, S., Arrowsmith, C.H., Edwards, A.M., Halabelian, L., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8shj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SHJ FirstGlance]. <br>
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Description: Crystal structure of the WD-repeat domain of human WDR91 in complex with MR45279
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZI8:N-[3-(4-chlorophenyl)oxetan-3-yl]-4-[(3S)-3-hydroxypyrrolidin-1-yl]benzamide'>ZI8</scene></td></tr>
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[[Category: Hutchinson, A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8shj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8shj OCA], [https://pdbe.org/8shj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8shj RCSB], [https://www.ebi.ac.uk/pdbsum/8shj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8shj ProSAT]</span></td></tr>
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[[Category: Edwards, A.M]]
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</table>
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[[Category: Arrowsmith, C.H]]
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== Function ==
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[[Category: Xu, J]]
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[https://www.uniprot.org/uniprot/WDR91_HUMAN WDR91_HUMAN] Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).[UniProtKB:Q7TMQ7]<ref>PMID:26783301</ref> <ref>PMID:27126989</ref>
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[[Category: Seitova, A]]
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== References ==
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[[Category: Dong, A]]
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<references/>
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[[Category: Structural Genomics Consortium (Sgc)]]
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__TOC__
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[[Category: Li, Y]]
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</StructureSection>
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[[Category: Halabelian, L]]
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[[Category: Homo sapiens]]
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[[Category: Brown, P.J]]
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[[Category: Large Structures]]
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[[Category: Ackloo, S]]
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[[Category: Ackloo S]]
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[[Category: Feng, J.W]]
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[[Category: Ahmad H]]
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[[Category: Zeng, H]]
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[[Category: Arrowsmith CH]]
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[[Category: Ahmad, H]]
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[[Category: Brown PJ]]
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[[Category: Dong A]]
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[[Category: Edwards AM]]
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[[Category: Feng JW]]
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[[Category: Halabelian L]]
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[[Category: Hutchinson A]]
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[[Category: Li Y]]
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[[Category: Seitova A]]
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[[Category: Xu J]]
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[[Category: Zeng H]]

Current revision

Crystal structure of the WD-repeat domain of human WDR91 in complex with MR45279

PDB ID 8shj

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