7stx
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ==== | + | ==Cryo-EM structure of human NatB in complex with CoA-Alpha-Synuclein== |
| - | <StructureSection load='7stx' size='340' side='right'caption='[[7stx]]' scene=''> | + | <StructureSection load='7stx' size='340' side='right'caption='[[7stx]], [[Resolution|resolution]] 3.14Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7stx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7STX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7STX FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7stx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7stx OCA], [https://pdbe.org/7stx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7stx RCSB], [https://www.ebi.ac.uk/pdbsum/7stx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7stx ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.14Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7stx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7stx OCA], [https://pdbe.org/7stx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7stx RCSB], [https://www.ebi.ac.uk/pdbsum/7stx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7stx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/NAA20_HUMAN NAA20_HUMAN] Autosomal recessive non-syndromic intellectual disability. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NAA20_HUMAN NAA20_HUMAN] Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln (PubMed:34230638). Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.<ref>PMID:18570629</ref> <ref>PMID:34230638</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Alpha-synuclein|Alpha-synuclein]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Deng S]] |
| + | [[Category: Marmorstein R]] | ||
Current revision
Cryo-EM structure of human NatB in complex with CoA-Alpha-Synuclein
| |||||||||||
