7wjq
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7wjq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WJQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WJQ FirstGlance]. <br> | <table><tr><td colspan='2'>[[7wjq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WJQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WJQ FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wjq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wjq OCA], [https://pdbe.org/7wjq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wjq RCSB], [https://www.ebi.ac.uk/pdbsum/7wjq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wjq ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wjq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wjq OCA], [https://pdbe.org/7wjq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wjq RCSB], [https://www.ebi.ac.uk/pdbsum/7wjq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wjq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/IPA7_SHIFL IPA7_SHIFL] E3 ubiquitin ligase effector protein that interferes with host's ubiquitination pathway (PubMed:30872533). Functions to alter host cell physiology and promote bacterial survival in host tissues (PubMed:30872533). Catalyzes ubiquitination of mouse Nlrp1b allele 1 protein, releasing the cleaved C-terminal part of Nlrp1b, which polymerizes and forms the Nlrp1b inflammasome followed by host cell pyroptosis (PubMed:30872533).<ref>PMID:30872533</ref> | [https://www.uniprot.org/uniprot/IPA7_SHIFL IPA7_SHIFL] E3 ubiquitin ligase effector protein that interferes with host's ubiquitination pathway (PubMed:30872533). Functions to alter host cell physiology and promote bacterial survival in host tissues (PubMed:30872533). Catalyzes ubiquitination of mouse Nlrp1b allele 1 protein, releasing the cleaved C-terminal part of Nlrp1b, which polymerizes and forms the Nlrp1b inflammasome followed by host cell pyroptosis (PubMed:30872533).<ref>PMID:30872533</ref> | ||
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| + | ==See Also== | ||
| + | *[[Gasdermin 3D structures|Gasdermin 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Crystal structure of GSDMB in complex with Ipah7.8
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