1lfp

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[[Image:1lfp.gif|left|200px]]
[[Image:1lfp.gif|left|200px]]
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{{Structure
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK00110 PRK00110]</span>
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{{STRUCTURE_1lfp| PDB=1lfp | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lfp OCA], [http://www.ebi.ac.uk/pdbsum/1lfp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lfp RCSB]</span>
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'''Crystal Structure of a Conserved Hypothetical Protein Aq1575 from Aquifex Aeolicus'''
'''Crystal Structure of a Conserved Hypothetical Protein Aq1575 from Aquifex Aeolicus'''
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[[Category: Shin, D H.]]
[[Category: Shin, D H.]]
[[Category: Yokota, H.]]
[[Category: Yokota, H.]]
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[[Category: berkeley structural genomics center]]
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[[Category: Berkeley structural genomics center]]
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[[Category: bsgc structure funded by nih]]
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[[Category: Bsgc structure funded by nih]]
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[[Category: hypothetical]]
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[[Category: Hypothetical]]
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[[Category: new fold]]
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[[Category: New fold]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi]]
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[[Category: Psi]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: thermostability]]
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[[Category: Thermostability]]
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Revision as of 20:52, 2 May 2008

Image:1lfp.gif

Template:STRUCTURE 1lfp

Crystal Structure of a Conserved Hypothetical Protein Aq1575 from Aquifex Aeolicus


Overview

The crystal structure of a conserved hypothetical protein, Aq1575, from Aquifex aeolicus has been determined by using x-ray crystallography. The protein belongs to the domain of unknown function DUF28 in the Pfam and PALI databases for which there was no structural information available until now. A structural homology search with the DALI algorithm indicates that this protein has a new fold with no obvious similarity to those of other proteins of known three-dimensional structure. The protein reveals a monomer consisting of three domains arranged along a pseudo threefold symmetry axis. There is a large cleft with approximate dimensions of 10 A x 10 A x 20 A in the center of the three domains along the symmetry axis. Two possible active sites are suggested based on the structure and multiple sequence alignment. There are several highly conserved residues in these putative active sites. The structure based molecular properties and thermostability of the protein are discussed.

About this Structure

1LFP is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of conserved hypothetical protein Aq1575 from Aquifex aeolicus., Shin DH, Yokota H, Kim R, Kim SH, Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7980-5. PMID:12060744 Page seeded by OCA on Fri May 2 23:52:41 2008

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