8drn
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[8drn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DRN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DRN FirstGlance]. <br> | <table><tr><td colspan='2'>[[8drn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DRN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DRN FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8drn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8drn OCA], [https://pdbe.org/8drn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8drn RCSB], [https://www.ebi.ac.uk/pdbsum/8drn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8drn ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.12Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8drn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8drn OCA], [https://pdbe.org/8drn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8drn RCSB], [https://www.ebi.ac.uk/pdbsum/8drn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8drn ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/LRC8C_MOUSE LRC8C_MOUSE] Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:29769723). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity). May play a role in adipogenesis (PubMed:15184384, PubMed:15564382, PubMed:21804215).[UniProtKB:Q8TDW0]<ref>PMID:15184384</ref> <ref>PMID:15564382</ref> <ref>PMID:21804215</ref> <ref>PMID:29769723</ref> | [https://www.uniprot.org/uniprot/LRC8C_MOUSE LRC8C_MOUSE] Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:29769723). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity). May play a role in adipogenesis (PubMed:15184384, PubMed:15564382, PubMed:21804215).[UniProtKB:Q8TDW0]<ref>PMID:15184384</ref> <ref>PMID:15564382</ref> <ref>PMID:21804215</ref> <ref>PMID:29769723</ref> | ||
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| + | ==See Also== | ||
| + | *[[Ion channels 3D structures|Ion channels 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 05:53, 5 July 2023
LRRC8A:C conformation 1 (round) LRR focus 1
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