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4kkx

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Current revision (06:07, 5 July 2023) (edit) (undo)
 
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<StructureSection load='4kkx' size='340' side='right'caption='[[4kkx]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
<StructureSection load='4kkx' size='340' side='right'caption='[[4kkx]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kkx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_typhimurium"_loeffler_1892 "bacillus typhimurium" loeffler 1892]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KKX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kkx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KKX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AQ3:N-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-3-[(2-HYDROXYPHENYL)AMINO]-D-ALANINE'>AQ3</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=F6F:2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL+DIHYDROGEN+PHOSPHATE'>F6F</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4hpj|4hpj]], [[2clm|2clm]], [[2clf|2clf]], [[2cle|2cle]], [[3cep|3cep]], [[3pr2|3pr2]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AQ3:N-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-3-[(2-HYDROXYPHENYL)AMINO]-D-ALANINE'>AQ3</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=F6F:2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL+DIHYDROGEN+PHOSPHATE'>F6F</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">trpA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 "Bacillus typhimurium" Loeffler 1892]), trpB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 "Bacillus typhimurium" Loeffler 1892])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kkx OCA], [https://pdbe.org/4kkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kkx RCSB], [https://www.ebi.ac.uk/pdbsum/4kkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kkx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kkx OCA], [https://pdbe.org/4kkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kkx RCSB], [https://www.ebi.ac.uk/pdbsum/4kkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kkx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TRPA_SALTY TRPA_SALTY]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [[https://www.uniprot.org/uniprot/TRPB_SALTY TRPB_SALTY]] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
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[https://www.uniprot.org/uniprot/TRPA_SALTY TRPA_SALTY] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus typhimurium loeffler 1892]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Tryptophan synthase]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Dunn, M F]]
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[[Category: Dunn MF]]
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[[Category: Fan, L]]
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[[Category: Fan L]]
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[[Category: Hilario, E]]
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[[Category: Hilario E]]
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[[Category: Mueller, L J]]
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[[Category: Mueller LJ]]
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[[Category: Niks, D]]
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[[Category: Niks D]]
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[[Category: 2-aminophenol quinonoid]]
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[[Category: Allosteric enzyme]]
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[[Category: Aromatic amino acid biosynthesis]]
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[[Category: Biosynthesis]]
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[[Category: Carbon-oxygen lyase]]
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[[Category: F6f]]
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[[Category: Lyase]]
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[[Category: Lyase-lyase inhibitor complex]]
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[[Category: Pyridoxal phosphate]]
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[[Category: Tryptophan biosynthesis]]
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Current revision

Crystal structure of Tryptophan Synthase from Salmonella typhimurium with 2-aminophenol quinonoid in the beta site and the F6 inhibitor in the alpha site

PDB ID 4kkx

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