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5e5l

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==Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 1 at 1.89 Angstrom==
==Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 1 at 1.89 Angstrom==
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<StructureSection load='5e5l' size='340' side='right' caption='[[5e5l]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
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<StructureSection load='5e5l' size='340' side='right'caption='[[5e5l]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5e5l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E5L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E5L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5e5l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E5L FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5du7|5du7]], [[5duj|5duj]], [[5dvp|5dvp]], [[5dvq|5dvq]], [[5dwt|5dwt]], [[5dzj|5dzj]], [[5dzp|5dzp]], [[5e1g|5e1g]], [[5e1i|5e1i]], [[5e51|5e51]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ldtA, Rv0116c, RVBD_0116c, P425_00122 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e5l OCA], [https://pdbe.org/5e5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e5l RCSB], [https://www.ebi.ac.uk/pdbsum/5e5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e5l ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e5l OCA], [http://pdbe.org/5e5l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e5l RCSB], [http://www.ebi.ac.uk/pdbsum/5e5l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e5l ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LDT1_MYCTU LDT1_MYCTU]] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems. Is thought to play a role in adaptation to the nonreplicative state of M.tuberculosis.<ref>PMID:18408028</ref> <ref>PMID:24041897</ref>
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[https://www.uniprot.org/uniprot/LDT1_MYCTU LDT1_MYCTU] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems. Is thought to play a role in adaptation to the nonreplicative state of M.tuberculosis.<ref>PMID:18408028</ref> <ref>PMID:24041897</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Myctu]]
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[[Category: Large Structures]]
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[[Category: Ginell, S L]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Kumar, P]]
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[[Category: Ginell SL]]
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[[Category: Lamichhane, G]]
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[[Category: Kumar P]]
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[[Category: Cell wall enzyme]]
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[[Category: Lamichhane G]]
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[[Category: Peptidoglycan synthesis enzyme]]
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[[Category: Transferase]]
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Revision as of 06:13, 5 July 2023

Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 1 at 1.89 Angstrom

PDB ID 5e5l

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