5ed9

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<StructureSection load='5ed9' size='340' side='right'caption='[[5ed9]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
<StructureSection load='5ed9' size='340' side='right'caption='[[5ed9]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ed9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ED9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ED9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ed9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ED9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ED9 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ed8|5ed8]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.009&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sun2, Unc84b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ed9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ed9 OCA], [https://pdbe.org/5ed9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ed9 RCSB], [https://www.ebi.ac.uk/pdbsum/5ed9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ed9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ed9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ed9 OCA], [http://pdbe.org/5ed9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ed9 RCSB], [http://www.ebi.ac.uk/pdbsum/5ed9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ed9 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SUN2_MOUSE SUN2_MOUSE]] Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, Syne2 and Sun2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for Rab5-GDP and participate in the activation of Rab5.<ref>PMID:16380439</ref> <ref>PMID:19509342</ref> <ref>PMID:19843581</ref> <ref>PMID:19874786</ref> <ref>PMID:20724637</ref>
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[https://www.uniprot.org/uniprot/SUN2_MOUSE SUN2_MOUSE] Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, Syne2 and Sun2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for Rab5-GDP and participate in the activation of Rab5.<ref>PMID:16380439</ref> <ref>PMID:19509342</ref> <ref>PMID:19843581</ref> <ref>PMID:19874786</ref> <ref>PMID:20724637</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Feng, W]]
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[[Category: Feng W]]
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[[Category: Gao, F]]
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[[Category: Gao F]]
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[[Category: Gong, W M]]
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[[Category: Gong WM]]
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[[Category: Huo, L]]
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[[Category: Huo L]]
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[[Category: Ke, H M]]
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[[Category: Ke HM]]
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[[Category: Nie, S]]
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[[Category: Nie S]]
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[[Category: Ren, J Q]]
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[[Category: Ren JQ]]
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[[Category: Wang, M Z]]
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[[Category: Wang MZ]]
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[[Category: Coiled-coil]]
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[[Category: Transport protein]]
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Revision as of 06:21, 5 July 2023

Crystal structure of CC1 of mouse SUN2

PDB ID 5ed9

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