5eh0
From Proteopedia
(Difference between revisions)
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<StructureSection load='5eh0' size='340' side='right'caption='[[5eh0]], [[Resolution|resolution]] 2.18Å' scene=''> | <StructureSection load='5eh0' size='340' side='right'caption='[[5eh0]], [[Resolution|resolution]] 2.18Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[5eh0]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5eh0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EH0 FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5NW:N2-(2-METHOXY-4-(1-METHYL-1H-PYRAZOL-4-YL)PHENYL)-N8-NEOPENTYLPYRIDO[3,4-D]PYRIMIDINE-2,8-DIAMINE'>5NW</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18Å</td></tr> |
- | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5NW:N2-(2-METHOXY-4-(1-METHYL-1H-PYRAZOL-4-YL)PHENYL)-N8-NEOPENTYLPYRIDO[3,4-D]PYRIMIDINE-2,8-DIAMINE'>5NW</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> | |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eh0 OCA], [https://pdbe.org/5eh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eh0 RCSB], [https://www.ebi.ac.uk/pdbsum/5eh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eh0 ProSAT]</span></td></tr> | |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
- | [ | + | [https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Homo sapiens]] |
- | + | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: Baker | + | [[Category: Baker R]] |
- | [[Category: Blagg | + | [[Category: Blagg J]] |
- | [[Category: Box | + | [[Category: Box G]] |
- | + | [[Category: Burke R]] | |
- | [[Category: Burke | + | [[Category: Cronin N]] |
- | [[Category: Cronin | + | [[Category: De Haven Brandon A]] |
- | [[Category: | + | [[Category: Eccles SA]] |
- | [[Category: | + | [[Category: Faisal A]] |
- | [[Category: | + | [[Category: Hayes A]] |
- | [[Category: Hayes | + | [[Category: Henley AT]] |
- | [[Category: Henley | + | [[Category: Hoelder S]] |
- | [[Category: Hoelder | + | [[Category: Innocenti P]] |
- | [[Category: Innocenti | + | [[Category: Linardopoulos S]] |
- | [[Category: Linardopoulos | + | [[Category: Mak G]] |
- | [[Category: Mak | + | [[Category: Naud N]] |
- | [[Category: | + | [[Category: O'Fee L]] |
- | [[Category: | + | [[Category: Raymaud FI]] |
- | [[Category: Raymaud | + | [[Category: Roberts J]] |
- | [[Category: Roberts | + | [[Category: Saville J]] |
- | [[Category: Saville | + | [[Category: Schmitt J]] |
- | [[Category: Schmitt | + | [[Category: Solanki S]] |
- | [[Category: Solanki | + | [[Category: Valenti M]] |
- | [[Category: Valenti | + | [[Category: Westwood IM]] |
- | [[Category: Westwood | + | [[Category: Woodward HL]] |
- | [[Category: Woodward | + | [[Category: Van Montfort RLM]] |
- | [[Category: | + |
Current revision
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach
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Categories: Homo sapiens | Large Structures | Baker R | Blagg J | Box G | Burke R | Cronin N | De Haven Brandon A | Eccles SA | Faisal A | Hayes A | Henley AT | Hoelder S | Innocenti P | Linardopoulos S | Mak G | Naud N | O'Fee L | Raymaud FI | Roberts J | Saville J | Schmitt J | Solanki S | Valenti M | Westwood IM | Woodward HL | Van Montfort RLM