5eho
From Proteopedia
(Difference between revisions)
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==Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach== | ==Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach== | ||
| - | <StructureSection load='5eho' size='340' side='right' caption='[[5eho]], [[Resolution|resolution]] 2.18Å' scene=''> | + | <StructureSection load='5eho' size='340' side='right'caption='[[5eho]], [[Resolution|resolution]] 2.18Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5eho]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5eho]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EHO FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5O1:~{N}8-CYCLOHEXYL-~{N}2-[2-METHOXY-4-(1-METHYLPYRAZOL-4-YL)PHENYL]PYRIDO[3,4-D]PYRIMIDINE-2,8-DIAMINE'>5O1</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5O1:~{N}8-CYCLOHEXYL-~{N}2-[2-METHOXY-4-(1-METHYLPYRAZOL-4-YL)PHENYL]PYRIDO[3,4-D]PYRIMIDINE-2,8-DIAMINE'>5O1</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eho OCA], [https://pdbe.org/5eho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eho RCSB], [https://www.ebi.ac.uk/pdbsum/5eho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eho ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> |
==See Also== | ==See Also== | ||
| - | *[[Dual specificity protein kinase|Dual specificity protein kinase]] | + | *[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Baker | + | [[Category: Baker R]] |
| - | [[Category: Blagg | + | [[Category: Blagg J]] |
| - | [[Category: Box | + | [[Category: Box G]] |
| - | + | [[Category: Burke R]] | |
| - | [[Category: Burke | + | [[Category: Cronin N]] |
| - | [[Category: Cronin | + | [[Category: De Haven Brandon A]] |
| - | [[Category: | + | [[Category: Eccles SA]] |
| - | [[Category: | + | [[Category: Faisal A]] |
| - | [[Category: | + | [[Category: Hayes A]] |
| - | [[Category: Hayes | + | [[Category: Henley AT]] |
| - | [[Category: Henley | + | [[Category: Hoelder S]] |
| - | [[Category: Hoelder | + | [[Category: Innocenti P]] |
| - | [[Category: Innocenti | + | [[Category: Linardopoulos S]] |
| - | [[Category: Linardopoulos | + | [[Category: Mak G]] |
| - | [[Category: Mak | + | [[Category: Naud N]] |
| - | [[Category: | + | [[Category: O'Fee L]] |
| - | [[Category: | + | [[Category: Raymaud FI]] |
| - | [[Category: Raymaud | + | [[Category: Roberts J]] |
| - | [[Category: Roberts | + | [[Category: Saville J]] |
| - | [[Category: Saville | + | [[Category: Schmitt J]] |
| - | [[Category: Schmitt | + | [[Category: Solanki S]] |
| - | [[Category: Solanki | + | [[Category: Valenti M]] |
| - | [[Category: Valenti | + | [[Category: Westwood IM]] |
| - | [[Category: Westwood | + | [[Category: Woodward HL]] |
| - | [[Category: Woodward | + | [[Category: Van Montfort RLM]] |
| - | [[Category: | + | |
Current revision
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach
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Categories: Homo sapiens | Large Structures | Baker R | Blagg J | Box G | Burke R | Cronin N | De Haven Brandon A | Eccles SA | Faisal A | Hayes A | Henley AT | Hoelder S | Innocenti P | Linardopoulos S | Mak G | Naud N | O'Fee L | Raymaud FI | Roberts J | Saville J | Schmitt J | Solanki S | Valenti M | Westwood IM | Woodward HL | Van Montfort RLM
