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1lgy

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[[Image:1lgy.jpg|left|200px]]
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{{Structure
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|PDB= 1lgy |SIZE=350|CAPTION= <scene name='initialview01'>1lgy</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1lgy", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=CAT:Catalytic+Site'>CAT</scene>
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span>
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{{STRUCTURE_1lgy| PDB=1lgy | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lgy OCA], [http://www.ebi.ac.uk/pdbsum/1lgy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lgy RCSB]</span>
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'''LIPASE II FROM RHIZOPUS NIVEUS'''
'''LIPASE II FROM RHIZOPUS NIVEUS'''
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[[Category: Mikami, B.]]
[[Category: Mikami, B.]]
[[Category: Morita, Y.]]
[[Category: Morita, Y.]]
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[[Category: hydrolase (carboxylic ester)]]
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[[Category: Lipase]]
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[[Category: lipase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:54:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:02:40 2008''
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Revision as of 20:54, 2 May 2008

Image:1lgy.jpg

Template:STRUCTURE 1lgy

LIPASE II FROM RHIZOPUS NIVEUS


Overview

The crystal and molecular structure of Lipase II from Rhizopus niveus was analyzed using X-ray single crystal diffraction data at a resolution of 2.2 A. The structure was refined to an R-factor of 0.19 for all available data. This lipase was purified and crystallized as Lipase I, which contains two polypeptide chains combined through non-covalent interaction. However, during crystal growth, Lipase I was converted to Lipase II, which consists of a single polypeptide chain of 269 amino acid residues, by limited proteolysis. The structure of Lipase II shows a typical alpha/beta hydrolase fold containing the so-called nucleophilic elbow. The catalytic center of this enzyme is analogous to those of other neutral lipases and serine proteases. This catalytic center is sheltered by an alpha-helix lid, which appears in neutral lipases, opening the active site at the oil-water interface.

About this Structure

1LGY is a Single protein structure of sequence from Rhizopus niveus. Full crystallographic information is available from OCA.

Reference

The crystal structure of lipase II from Rhizopus niveus at 2.2 A resolution., Kohno M, Funatsu J, Mikami B, Kugimiya W, Matsuo T, Morita Y, J Biochem. 1996 Sep;120(3):505-10. PMID:8902613 Page seeded by OCA on Fri May 2 23:54:34 2008

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