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5ejw

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Current revision (06:31, 5 July 2023) (edit) (undo)
 
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<StructureSection load='5ejw' size='340' side='right'caption='[[5ejw]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5ejw' size='340' side='right'caption='[[5ejw]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ejw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EJW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EJW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ejw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EJW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5PZ:(1~{R})-2-[2-AZANYLIDENE-3-[(2-METHYLPHENYL)METHYL]BENZIMIDAZOL-1-YL]-1-(3,4-DICHLOROPHENYL)ETHANOL'>5PZ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cbx7, D15Ertd417e ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5PZ:(1~{R})-2-[2-AZANYLIDENE-3-[(2-METHYLPHENYL)METHYL]BENZIMIDAZOL-1-YL]-1-(3,4-DICHLOROPHENYL)ETHANOL'>5PZ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ejw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ejw OCA], [http://pdbe.org/5ejw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ejw RCSB], [http://www.ebi.ac.uk/pdbsum/5ejw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ejw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ejw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ejw OCA], [https://pdbe.org/5ejw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ejw RCSB], [https://www.ebi.ac.uk/pdbsum/5ejw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ejw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CBX7_MOUSE CBX7_MOUSE]] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to histone H3 trimethylated 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). May possibly also bind trimethylated lysine residues in other proteins (in vitro). Binds non-coding, single-stranded RNA. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.<ref>PMID:16537902</ref> <ref>PMID:20541999</ref>
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[https://www.uniprot.org/uniprot/CBX7_MOUSE CBX7_MOUSE] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to histone H3 trimethylated 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). May possibly also bind trimethylated lysine residues in other proteins (in vitro). Binds non-coding, single-stranded RNA. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.<ref>PMID:16537902</ref> <ref>PMID:20541999</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Ren, C]]
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[[Category: Ren C]]
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[[Category: Zhou, M M]]
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[[Category: Zhou MM]]
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[[Category: Inhibitor]]
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[[Category: Transcription]]
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[[Category: Transcription-inhibitor complex]]
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Current revision

Crystal structure of chromobox homolog 7 (CBX7) chromodomain with MS351

PDB ID 5ejw

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