5ele

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Current revision (06:32, 5 July 2023) (edit) (undo)
 
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<StructureSection load='5ele' size='340' side='right'caption='[[5ele]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='5ele' size='340' side='right'caption='[[5ele]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ele]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae_01 Vibrio cholerae 01]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ELE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ELE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ele]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1 Vibrio cholerae O1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ELE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ELE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=BCN:BICINE'>BCN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ctxB, toxB, VC_1456 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=127906 Vibrio cholerae 01])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=BCN:BICINE'>BCN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PRD_900128:Blood+group+A+Lewis+Y+antigen,+alpha+anomer'>PRD_900128</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ele FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ele OCA], [http://pdbe.org/5ele PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ele RCSB], [http://www.ebi.ac.uk/pdbsum/5ele PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ele ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ele FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ele OCA], [https://pdbe.org/5ele PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ele RCSB], [https://www.ebi.ac.uk/pdbsum/5ele PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ele ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CHTB_VIBCH CHTB_VIBCH]] The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.
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[https://www.uniprot.org/uniprot/CHTB_VIBCH CHTB_VIBCH] The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Vibrio cholerae 01]]
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[[Category: Vibrio cholerae O1]]
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[[Category: Burschowsky, D]]
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[[Category: Burschowsky D]]
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[[Category: Heggelund, J E]]
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[[Category: Heggelund JE]]
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[[Category: Krengel, U]]
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[[Category: Krengel U]]
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[[Category: A lewis-y]]
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[[Category: Blood group oligosaccharide/antigen]]
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[[Category: Cholera toxin b-pentamer]]
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[[Category: Complex]]
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[[Category: Toxin]]
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Current revision

Cholera toxin El Tor B-pentamer in complex with A Lewis-y

PDB ID 5ele

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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