1lj2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1lj2.gif|left|200px]]
[[Image:1lj2.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1lj2 |SIZE=350|CAPTION= <scene name='initialview01'>1lj2</scene>, resolution 2.38&Aring;
+
The line below this paragraph, containing "STRUCTURE_1lj2", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=AU:GOLD+ION'>AU</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1lj2| PDB=1lj2 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lj2 OCA], [http://www.ebi.ac.uk/pdbsum/1lj2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lj2 RCSB]</span>
+
-
}}
+
'''Recognition of eIF4G by Rotavirus NSP3 reveals a basis for mRNA circularization'''
'''Recognition of eIF4G by Rotavirus NSP3 reveals a basis for mRNA circularization'''
Line 27: Line 24:
[[Category: Burley, S K.]]
[[Category: Burley, S K.]]
[[Category: Groft, C M.]]
[[Category: Groft, C M.]]
-
[[Category: closed loop]]
+
[[Category: Closed loop]]
-
[[Category: coiled coil]]
+
[[Category: Coiled coil]]
-
[[Category: eif4g]]
+
[[Category: Eif4g]]
-
[[Category: homodimer]]
+
[[Category: Homodimer]]
-
[[Category: mrna]]
+
[[Category: Mrna]]
-
[[Category: nsp3]]
+
[[Category: Nsp3]]
-
[[Category: rotavirus]]
+
[[Category: Rotavirus]]
-
[[Category: translation]]
+
[[Category: Translation]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:58:01 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:03:23 2008''
+

Revision as of 20:58, 2 May 2008

Image:1lj2.gif

Template:STRUCTURE 1lj2

Recognition of eIF4G by Rotavirus NSP3 reveals a basis for mRNA circularization


Overview

Rotaviruses, segmented double-stranded RNA viruses, co-opt the eukaryotic translation machinery with the aid of nonstructural protein 3 (NSP3), a rotaviral functional homolog of the cellular poly(A) binding protein (PABP). NSP3 binds to viral mRNA 3' consensus sequences and circularizes mRNA via interactions with eIF4G. Here, we present the X-ray structure of the C-terminal domain of NSP3 (NSP3-C) recognizing a fragment of eIF4GI. Homodimerization of NSP3-C yields a symmetric, elongated, largely alpha-helical structure with two hydrophobic eIF4G binding pockets at the dimer interface. Site-directed mutagenesis and isothermal titration calorimetry documented that NSP3 and PABP use analogous eIF4G recognition strategies, despite marked differences in tertiary structure.

About this Structure

1LJ2 is a Protein complex structure of sequences from Simian rotavirus a/sa11. Full crystallographic information is available from OCA.

Reference

Recognition of eIF4G by rotavirus NSP3 reveals a basis for mRNA circularization., Groft CM, Burley SK, Mol Cell. 2002 Jun;9(6):1273-83. PMID:12086624 Page seeded by OCA on Fri May 2 23:58:01 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1lj2"
Personal tools