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5en2

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Current revision (08:08, 12 July 2023) (edit) (undo)
 
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<StructureSection load='5en2' size='340' side='right'caption='[[5en2]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
<StructureSection load='5en2' size='340' side='right'caption='[[5en2]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5en2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EN2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5en2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Argentinian_mammarenavirus Argentinian mammarenavirus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EN2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.821&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5en2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5en2 OCA], [http://pdbe.org/5en2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5en2 RCSB], [http://www.ebi.ac.uk/pdbsum/5en2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5en2 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5en2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5en2 OCA], [https://pdbe.org/5en2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5en2 RCSB], [https://www.ebi.ac.uk/pdbsum/5en2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5en2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GLYC_JUNIN GLYC_JUNIN]] Stable signal peptide (SSP) is cleaved but is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational cleavage of GP1 and GP2, glycoprotein transport to the cell plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion (By similarity). Glycoprotein G1 mediates virus attachment to host TFRC. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.<ref>PMID:19548229</ref> Glycoprotein G2 is a class I viral fusion protein, that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm. Membrane fusion is mediated by irreversable conformational changes induced upon acidification in the endosome (By similarity).
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[https://www.uniprot.org/uniprot/GLYC_JUNIN GLYC_JUNIN] Stable signal peptide (SSP) is cleaved but is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational cleavage of GP1 and GP2, glycoprotein transport to the cell plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion (By similarity). Glycoprotein G1 mediates virus attachment to host TFRC. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.<ref>PMID:19548229</ref> Glycoprotein G2 is a class I viral fusion protein, that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm. Membrane fusion is mediated by irreversable conformational changes induced upon acidification in the endosome (By similarity).
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Argentinian mammarenavirus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Abraham, J]]
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[[Category: Abraham J]]
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[[Category: Briggiler, A]]
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[[Category: Briggiler A]]
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[[Category: Clark, L]]
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[[Category: Clark L]]
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[[Category: Enria, D]]
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[[Category: Enria D]]
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[[Category: Harrison, S C]]
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[[Category: Harrison SC]]
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[[Category: Levis, S]]
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[[Category: Levis S]]
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[[Category: Mahmutovic, S]]
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[[Category: Mahmutovic S]]
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[[Category: Complex]]
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[[Category: Glycoprotein]]
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[[Category: Immunoglobulin]]
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[[Category: Viral protein-immune system complex]]
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[[Category: Virus]]
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Current revision

Molecular basis for antibody-mediated neutralization of New World hemorrhagic fever mammarenaviruses

PDB ID 5en2

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