5enn

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Current revision (08:09, 12 July 2023) (edit) (undo)
 
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<StructureSection load='5enn' size='340' side='right'caption='[[5enn]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='5enn' size='340' side='right'caption='[[5enn]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5enn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ENN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ENN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5enn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ENN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ENN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5QS:1-[[4-(CYCLOPROPYLMETHYL)-5-[2-(PYRIDIN-4-YLAMINO)PYRIMIDIN-4-YL]PYRIMIDIN-2-YL]AMINO]-2-METHYL-PROPAN-2-OL'>5QS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ph4|4ph4]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5QS:1-[[4-(CYCLOPROPYLMETHYL)-5-[2-(PYRIDIN-4-YLAMINO)PYRIMIDIN-4-YL]PYRIMIDIN-2-YL]AMINO]-2-METHYL-PROPAN-2-OL'>5QS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIK3C3, VPS34 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5enn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5enn OCA], [https://pdbe.org/5enn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5enn RCSB], [https://www.ebi.ac.uk/pdbsum/5enn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5enn ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5enn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5enn OCA], [http://pdbe.org/5enn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5enn RCSB], [http://www.ebi.ac.uk/pdbsum/5enn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5enn ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN]] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>
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[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Phosphatidylinositol 3-kinase]]
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[[Category: Kearney EP]]
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[[Category: Kearney, E P]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Vps34]]
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Current revision

The crystal structure of Human VPS34 in complex with a selective and potent inhibitor

PDB ID 5enn

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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