1lj9

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[[Image:1lj9.gif|left|200px]]
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{{Structure
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|PDB= 1lj9 |SIZE=350|CAPTION= <scene name='initialview01'>1lj9</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1lj9", creates the "Structure Box" on the page.
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|GENE= REF02436 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 Enterococcus faecalis])
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00347 HTH_MARR], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1846 MarR]</span>
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{{STRUCTURE_1lj9| PDB=1lj9 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lj9 OCA], [http://www.ebi.ac.uk/pdbsum/1lj9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lj9 RCSB]</span>
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'''The crystal structure of the transcriptional regulator SlyA'''
'''The crystal structure of the transcriptional regulator SlyA'''
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Revision as of 20:58, 2 May 2008

Image:1lj9.gif

Template:STRUCTURE 1lj9

The crystal structure of the transcriptional regulator SlyA


Overview

The crystal structure of a SlyA transcriptional regulator at 1.6 A resolution is presented, and structural relationships between members of the MarR/SlyA family are discussed. The SlyA family, which includes SlyA, Rap, Hor, and RovA proteins, is widely distributed in bacterial and archaeal genomes. Current evidence suggests that SlyA-like factors act as repressors, activators, and modulators of gene transcription. These proteins have been shown to up-regulate the expression of molecular chaperones, acid-resistance proteins, and cytolysin, and down-regulate several biosynthetic enzymes. The structure of SlyA from Enterococcus faecalis, determined as a part of an ongoing structural genomics initiative (www.mcsg.anl.gov), revealed the same winged helix DNA-binding motif that was recently found in the MarR repressor from Escherichia coli and the MexR repressor from Pseudomonas aeruginosa, a sequence homologue of MarR. Phylogenetic analysis of the MarR/SlyA family suggests that Sly is placed between the SlyA and MarR subfamilies and shows significant sequence similarity to members of both subfamilies.

About this Structure

1LJ9 is a Single protein structure of sequence from Enterococcus faecalis. Full crystallographic information is available from OCA.

Reference

Crystal structure of Enterococcus faecalis SlyA-like transcriptional factor., Wu RY, Zhang RG, Zagnitko O, Dementieva I, Maltzev N, Watson JD, Laskowski R, Gornicki P, Joachimiak A, J Biol Chem. 2003 May 30;278(22):20240-4. Epub 2003 Mar 20. PMID:12649270 Page seeded by OCA on Fri May 2 23:58:21 2008

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