5eth

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Current revision (08:23, 12 July 2023) (edit) (undo)
 
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<StructureSection load='5eth' size='340' side='right'caption='[[5eth]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='5eth' size='340' side='right'caption='[[5eth]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5eth]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ETH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ETH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5eth]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ETH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ETH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5RT:1-METHYL-~{N}-(1-THIOPHEN-2-YLCARBONYL-3,4-DIHYDRO-2~{H}-QUINOLIN-6-YL)-~{N}-[2,2,2-TRIS(FLUORANYL)ETHYL]INDOLE-4-SULFONAMIDE'>5RT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.803&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RORC, NR1F3, RORG, RZRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5RT:1-METHYL-~{N}-(1-THIOPHEN-2-YLCARBONYL-3,4-DIHYDRO-2~{H}-QUINOLIN-6-YL)-~{N}-[2,2,2-TRIS(FLUORANYL)ETHYL]INDOLE-4-SULFONAMIDE'>5RT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5eth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eth OCA], [http://pdbe.org/5eth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eth RCSB], [http://www.ebi.ac.uk/pdbsum/5eth PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eth ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eth OCA], [https://pdbe.org/5eth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eth RCSB], [https://www.ebi.ac.uk/pdbsum/5eth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eth ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
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[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Marcotte, D M]]
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[[Category: Marcotte DM]]
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[[Category: Inverse agonist]]
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[[Category: Ror gamma]]
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[[Category: Transcription]]
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Current revision

RORy in complex with inverse agonist 3.

PDB ID 5eth

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