5ezn

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Current revision (08:36, 12 July 2023) (edit) (undo)
 
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<StructureSection load='5ezn' size='340' side='right'caption='[[5ezn]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
<StructureSection load='5ezn' size='340' side='right'caption='[[5ezn]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ezn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EZN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EZN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ezn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EZN FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ezn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ezn OCA], [http://pdbe.org/5ezn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ezn RCSB], [http://www.ebi.ac.uk/pdbsum/5ezn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ezn ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ezn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ezn OCA], [https://pdbe.org/5ezn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ezn RCSB], [https://www.ebi.ac.uk/pdbsum/5ezn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ezn ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CYRPA_PLAF7 CYRPA_PLAF7] Essential for the invasion of host erythrocytes by blood stage merozoites (PubMed:22593616, PubMed:25583518, PubMed:27374406, PubMed:28195530, PubMed:28195038). Required for the assembly of the PfRH5 adhesion complex (or invasion complex) composed of CyRPA, RH5 and RIPR at the interface between the merozoite and the host erythrocyte membranes (PubMed:25583518, PubMed:28186186, PubMed:28195530, PubMed:28195038, PubMed:30542156). This facilitates the binding of RH5 to host receptor BSG/basigin, which leads to the establishment of a tight junction between the merozoite and host erythrocyte membranes and allows Ca(2+) release into the erythrocyte (PubMed:27374406, PubMed:28186186, PubMed:30542156).<ref>PMID:22593616</ref> <ref>PMID:25583518</ref> <ref>PMID:27374406</ref> <ref>PMID:28186186</ref> <ref>PMID:28195038</ref> <ref>PMID:28195530</ref> <ref>PMID:30542156</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Favuzza, P]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Pluschke, G]]
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[[Category: Favuzza P]]
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[[Category: Rudolph, M G]]
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[[Category: Pluschke G]]
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[[Category: Cyrpa]]
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[[Category: Rudolph MG]]
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[[Category: Fab]]
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[[Category: Immune system]]
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[[Category: Malaria inhibitory antibody]]
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Current revision

Crystal Structure of PfCyRPA

PDB ID 5ezn

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