1lk5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1lk5.jpg|left|200px]]
[[Image:1lk5.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1lk5 |SIZE=350|CAPTION= <scene name='initialview01'>1lk5</scene>, resolution 1.75&Aring;
+
The line below this paragraph, containing "STRUCTURE_1lk5", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribose-5-phosphate_isomerase Ribose-5-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.6 5.3.1.6] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1lk5| PDB=1lk5 | SCENE= }}
-
|RELATEDENTRY=[[1lk7|1LK7]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lk5 OCA], [http://www.ebi.ac.uk/pdbsum/1lk5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lk5 RCSB]</span>
+
-
}}
+
'''Structure of the D-Ribose-5-Phosphate Isomerase from Pyrococcus horikoshii'''
'''Structure of the D-Ribose-5-Phosphate Isomerase from Pyrococcus horikoshii'''
Line 34: Line 31:
[[Category: Payan, F.]]
[[Category: Payan, F.]]
[[Category: Roussel, A.]]
[[Category: Roussel, A.]]
-
[[Category: alpha/beta structure]]
+
[[Category: Alpha/beta structure]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:59:53 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:03:46 2008''
+

Revision as of 20:59, 2 May 2008

Image:1lk5.jpg

Template:STRUCTURE 1lk5

Structure of the D-Ribose-5-Phosphate Isomerase from Pyrococcus horikoshii


Overview

A gene homologous to D-ribose-5-phosphate isomerase (EC 5.3.1.6) was found in the genome of Pyrococcus horikoshii. D-ribose-5-phosphate isomerase (PRI) is of particular metabolic importance since it catalyzes the interconversion between the ribose and ribulose forms involved in the pentose phosphate cycle and in the process of photosynthesis. The gene consisting of 687 bp was overexpressed in Escherichia coli, and the resulting enzyme showed activity at high temperatures with an optimum over 90 degrees C. The crystal structures of the enzyme, free and in complex with D-4-phosphoerythronic acid inhibitor, were determined. PRI is a tetramer in the crystal and in solution, and each monomer has a new fold consisting of two alpha/beta domains. The 3D structures and the characterization of different mutants indicate a direct or indirect catalytic role for the residues E107, D85, and K98.

About this Structure

1LK5 is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

Reference

A hyperthermostable D-ribose-5-phosphate isomerase from Pyrococcus horikoshii characterization and three-dimensional structure., Ishikawa K, Matsui I, Payan F, Cambillau C, Ishida H, Kawarabayasi Y, Kikuchi H, Roussel A, Structure. 2002 Jun;10(6):877-86. PMID:12057201 Page seeded by OCA on Fri May 2 23:59:53 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1lk5"
Personal tools