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1lkb

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[[Image:1lkb.jpg|left|200px]]
[[Image:1lkb.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1lkb |SIZE=350|CAPTION= <scene name='initialview01'>1lkb</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1lkb", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1lkb| PDB=1lkb | SCENE= }}
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|RELATEDENTRY=[[1lka|1LKA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lkb OCA], [http://www.ebi.ac.uk/pdbsum/1lkb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lkb RCSB]</span>
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}}
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'''Porcine Pancreatic Elastase/Na-Complex'''
'''Porcine Pancreatic Elastase/Na-Complex'''
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[[Category: Tucker, P A.]]
[[Category: Tucker, P A.]]
[[Category: Weiss, M S.]]
[[Category: Weiss, M S.]]
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[[Category: beta-barrel]]
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[[Category: Beta-barrel]]
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[[Category: chloride binding]]
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[[Category: Chloride binding]]
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[[Category: chymotrypsin-fold]]
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[[Category: Chymotrypsin-fold]]
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[[Category: sodium binding]]
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[[Category: Sodium binding]]
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[[Category: sulfate binding]]
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[[Category: Sulfate binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:00:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:03:51 2008''
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Revision as of 21:00, 2 May 2008

Image:1lkb.jpg

Template:STRUCTURE 1lkb

Porcine Pancreatic Elastase/Na-Complex


Overview

Porcine pancreatic elastase has been crystallized at slightly acidic pH under two similar but slightly different conditions. Diffraction data were collected at a wavelength of 1.5 A to a maximum resolution of 1.7 A. Both difference electron-density maps and anomalous difference electron-density maps suggest that in crystals grown from a sodium sulfate solution PPE binds Na(+) in its metal-binding site. In contrast, PPE binds Ca(2+) in crystals grown from a solution containing sodium citrate and calcium chloride. This observation is in contradiction to most PPE structures reported in the PDB. In addition to the metal-binding site, up to three other binding sites, which appear to be anion-binding sites, could be identified based on the observed anomalous intensity differences.

About this Structure

1LKB is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Metal binding to porcine pancreatic elastase: calcium or not calcium., Weiss MS, Panjikar S, Nowak E, Tucker PA, Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1407-12. Epub 2002, Aug 23. PMID:12198296 Page seeded by OCA on Sat May 3 00:00:11 2008

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