1lkf
From Proteopedia
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'''LEUKOCIDIN F (HLGB) FROM STAPHYLOCOCCUS AUREUS''' | '''LEUKOCIDIN F (HLGB) FROM STAPHYLOCOCCUS AUREUS''' | ||
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[[Category: Olson, R.]] | [[Category: Olson, R.]] | ||
[[Category: Yokota, K.]] | [[Category: Yokota, K.]] | ||
| - | [[Category: | + | [[Category: Hemolysin]] |
| - | [[Category: | + | [[Category: Leukotoxin]] |
| - | [[Category: | + | [[Category: Pore-forming toxin]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:00:27 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 21:00, 2 May 2008
LEUKOCIDIN F (HLGB) FROM STAPHYLOCOCCUS AUREUS
Overview
Staphylococcal LukF, LukS, HgammaII, and alpha-hemolysin are self-assembling, channel-forming proteins related in sequence and function. In the alpha-hemolysin heptamer, the channel-forming beta-strands and the amino latch make long excursions from the protomer core. Here we report the crystal structure of the water soluble form of LukF. In the LukF structure the channel-forming region folds into an amphipathic, three-strand beta-sheet and the amino latch forms a beta-strand extending a central beta-sheet. The LukF structure illustrates how a channel-forming toxin masks protein-protein and protein-membrane interfaces prior to cell binding and assembly, and together with the alpha-hemolysin heptamer structure, they define the end points on the pathway of toxin assembly.
About this Structure
1LKF is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
Crystal structure of staphylococcal LukF delineates conformational changes accompanying formation of a transmembrane channel., Olson R, Nariya H, Yokota K, Kamio Y, Gouaux E, Nat Struct Biol. 1999 Feb;6(2):134-40. PMID:10048924 Page seeded by OCA on Sat May 3 00:00:27 2008
