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1ll5

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[[Image:1ll5.gif|left|200px]]
[[Image:1ll5.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ll5 |SIZE=350|CAPTION= <scene name='initialview01'>1ll5</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1ll5", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=IM2:3-(2-FORMIMIDOYLAMINO-ETHYLSULFANYL)-5-(1-FORMYL-2-HYDROXY-PROPYL)-4,5-DIHYDRO-1H-PYRROLE-2-CARBOXYLIC+ACID'>IM2</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= K12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_1ll5| PDB=1ll5 | SCENE= }}
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|RELATEDENTRY=[[1ke4|1KE4]], [[1fco|1FCO]], [[1bt5|1BT5]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ll5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ll5 OCA], [http://www.ebi.ac.uk/pdbsum/1ll5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ll5 RCSB]</span>
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}}
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'''X-ray crystal structure of AmpC WT beta-lactamase in complex with covalently bound imipenem'''
'''X-ray crystal structure of AmpC WT beta-lactamase in complex with covalently bound imipenem'''
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[[Category: Beadle, B M.]]
[[Category: Beadle, B M.]]
[[Category: Shoichet, B K.]]
[[Category: Shoichet, B K.]]
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[[Category: beta-lactamase]]
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[[Category: Beta-lactamase]]
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[[Category: carbapenem]]
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[[Category: Carbapenem]]
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[[Category: imipenem]]
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[[Category: Imipenem]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:01:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:04:09 2008''
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Revision as of 21:01, 2 May 2008

Image:1ll5.gif

Template:STRUCTURE 1ll5

X-ray crystal structure of AmpC WT beta-lactamase in complex with covalently bound imipenem


Overview

To determine how imipenem inhibits the class C beta-lactamase AmpC, the X-ray crystal structure of the acyl-enzyme complex was determined to a resolution of 1.80 A. In the complex, the lactam carbonyl oxygen of imipenem has flipped by approximately 180 degrees compared to its expected position; the electrophilic acyl center is thus displaced from the point of hydrolytic attack. This conformation resembles that of imipenem bound to the class A enzyme TEM-1 but is different from that of moxalactam bound to AmpC.

About this Structure

1LL5 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis for imipenem inhibition of class C beta-lactamases., Beadle BM, Shoichet BK, Antimicrob Agents Chemother. 2002 Dec;46(12):3978-80. PMID:12435704 Page seeded by OCA on Sat May 3 00:01:42 2008

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