3knx

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<StructureSection load='3knx' size='340' side='right'caption='[[3knx]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
<StructureSection load='3knx' size='340' side='right'caption='[[3knx]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3knx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hcv Hcv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KNX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KNX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3knx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_(isolate_H77) Hepatitis C virus (isolate H77)] and [https://en.wikipedia.org/wiki/Hepatitis_C_virus_genotype_1a Hepatitis C virus genotype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KNX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KNX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=JZT:(2R)-2-{(3S,13S,16AS,17AR,17BS)-13-[({(1S)-1-[(4,4-DIMETHYL-2,6-DIOXOPIPERIDIN-1-YL)METHYL]-2,2-DIMETHYLPROPYL}CARBAMOYL)AMINO]-17,17-DIMETHYL-1,14-DIOXOOCTADECAHYDRO-2H-CYCLOPROPA[3,4]PYRROLO[1,2-A][1,4]DIAZACYCLOHEXADECIN-3-YL}-2-HYDROXY-N-PROP-2-EN-1-YLETHANAMIDE'>JZT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3eyd|3eyd]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=JZT:(2R)-2-{(3S,13S,16AS,17AR,17BS)-13-[({(1S)-1-[(4,4-DIMETHYL-2,6-DIOXOPIPERIDIN-1-YL)METHYL]-2,2-DIMETHYLPROPYL}CARBAMOYL)AMINO]-17,17-DIMETHYL-1,14-DIOXOOCTADECAHYDRO-2H-CYCLOPROPA[3,4]PYRROLO[1,2-A][1,4]DIAZACYCLOHEXADECIN-3-YL}-2-HYDROXY-N-PROP-2-EN-1-YLETHANAMIDE'>JZT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NS3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63746 HCV])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3knx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3knx OCA], [https://pdbe.org/3knx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3knx RCSB], [https://www.ebi.ac.uk/pdbsum/3knx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3knx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3knx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3knx OCA], [https://pdbe.org/3knx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3knx RCSB], [https://www.ebi.ac.uk/pdbsum/3knx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3knx ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9ELS8_9HEPC Q9ELS8_9HEPC]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hcv]]
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[[Category: Hepatitis C virus genotype 1a]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Agrawal, S]]
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[[Category: Agrawal S]]
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[[Category: Blackman, M]]
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[[Category: Blackman M]]
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[[Category: Bogen, S]]
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[[Category: Bogen S]]
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[[Category: Chase, R]]
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[[Category: Chase R]]
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[[Category: Chen, K X]]
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[[Category: Chen KX]]
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[[Category: Cheng, K C]]
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[[Category: Cheng K-C]]
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[[Category: Girijavallabhan, V]]
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[[Category: Girijavallabhan V]]
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[[Category: Hart, A]]
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[[Category: Hart A]]
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[[Category: Nair, L]]
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[[Category: Nair L]]
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[[Category: Njoroge, F G]]
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[[Category: Njoroge FG]]
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[[Category: Pichardo, J]]
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[[Category: Pichardo J]]
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[[Category: Piwinski, J]]
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[[Category: Piwinski J]]
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[[Category: Prongay, A]]
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[[Category: Prongay A]]
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[[Category: Shih, N Y]]
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[[Category: Shih N-Y]]
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[[Category: Tong, X]]
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[[Category: Tong X]]
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[[Category: Velazquez, F]]
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[[Category: Velazquez F]]
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[[Category: Venkatraman, S]]
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[[Category: Venkatraman S]]
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[[Category: Wu, W]]
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[[Category: Wu W]]
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[[Category: Atp-binding]]
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[[Category: Envelope protein]]
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[[Category: Helicase]]
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[[Category: Hepatitis c virus]]
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[[Category: Hydrolase]]
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[[Category: Macrocyclic ketoamide inhibitor]]
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[[Category: Membrane]]
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[[Category: Ns3 protease domain]]
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[[Category: Nucleotide-binding]]
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[[Category: Rna replication]]
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[[Category: Serine protease]]
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[[Category: Transmembrane]]
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[[Category: Viral protein]]
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Revision as of 06:34, 19 July 2023

HCV NS3 protease domain with P1-P3 macrocyclic ketoamide inhibitor

PDB ID 3knx

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