1llo

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[[Image:1llo.gif|left|200px]]
[[Image:1llo.gif|left|200px]]
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{{Structure
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|PDB= 1llo |SIZE=350|CAPTION= <scene name='initialview01'>1llo</scene>, resolution 1.85&Aring;
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The line below this paragraph, containing "STRUCTURE_1llo", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene>
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1llo| PDB=1llo | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1llo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1llo OCA], [http://www.ebi.ac.uk/pdbsum/1llo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1llo RCSB]</span>
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'''HEVAMINE A (A PLANT ENDOCHITINASE/LYSOZYME) COMPLEXED WITH ALLOSAMIDIN'''
'''HEVAMINE A (A PLANT ENDOCHITINASE/LYSOZYME) COMPLEXED WITH ALLOSAMIDIN'''
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[[Category: Kalk, K H.]]
[[Category: Kalk, K H.]]
[[Category: Scheltinga, A C.Terwisscha Van.]]
[[Category: Scheltinga, A C.Terwisscha Van.]]
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[[Category: chitinase]]
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[[Category: Chitinase]]
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[[Category: lysozyme]]
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[[Category: Lysozyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:02:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:04:16 2008''
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Revision as of 21:02, 2 May 2008

Image:1llo.gif

Template:STRUCTURE 1llo

HEVAMINE A (A PLANT ENDOCHITINASE/LYSOZYME) COMPLEXED WITH ALLOSAMIDIN


Overview

The plant enzyme hevamine has both chitinase and lysozyme activity. HPLC analysis of the products of the hydrolysis of chitopentaose shows that hevamine acts with retention of the configuration, despite the absence of a nucleophilic or stabilizing carboxylate. To analyze the stabilization of a putative oxocarbonium ion intermediate, the X-ray structure of hevamine complexed with the inhibitor allosamidin was determined at 1.85 A resolution. This structure supports the role of Glu127 as a proton donor. The allosamizoline group binds in the center of the active site, mimicking a reaction intermediate in which a positive charge at C1 is stabilized intramolecularly by the carbonyl oxygen of the N-acetyl group at C2.

About this Structure

1LLO is a Single protein structure of sequence from Hevea brasiliensis. Full crystallographic information is available from OCA.

Reference

Stereochemistry of chitin hydrolysis by a plant chitinase/lysozyme and X-ray structure of a complex with allosamidin: evidence for substrate assisted catalysis., Terwisscha van Scheltinga AC, Armand S, Kalk KH, Isogai A, Henrissat B, Dijkstra BW, Biochemistry. 1995 Dec 5;34(48):15619-23. PMID:7495789 Page seeded by OCA on Sat May 3 00:02:24 2008

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