5fbx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:45, 19 July 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='5fbx' size='340' side='right'caption='[[5fbx]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='5fbx' size='340' side='right'caption='[[5fbx]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5fbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FBX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FBX FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5fbx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FBX FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5W4:(3~{S})-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-2-METHYL-3-PHENYL-3~{H}-ISOINDOL-1-ONE'>5W4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5W4:(3~{S})-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-2-METHYL-3-PHENYL-3~{H}-ISOINDOL-1-ONE'>5W4</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fbx OCA], [http://pdbe.org/5fbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fbx RCSB], [http://www.ebi.ac.uk/pdbsum/5fbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fbx ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fbx OCA], [https://pdbe.org/5fbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fbx RCSB], [https://www.ebi.ac.uk/pdbsum/5fbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fbx ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
==See Also==
==See Also==
Line 19: Line 19:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bountra, C]]
+
[[Category: Bountra C]]
-
[[Category: Brennan, P E]]
+
[[Category: Brennan PE]]
-
[[Category: Clark, P G.K]]
+
[[Category: Clark PGK]]
-
[[Category: Delft, F von]]
+
[[Category: Dixon D]]
-
[[Category: Dixon, D]]
+
[[Category: Edwards AM]]
-
[[Category: Edwards, A M]]
+
[[Category: Fedorov O]]
-
[[Category: Fedorov, O]]
+
[[Category: Knapp S]]
-
[[Category: Knapp, S]]
+
[[Category: Muller S]]
-
[[Category: Muller, S]]
+
[[Category: Nowak R]]
-
[[Category: Nowak, R]]
+
[[Category: Siejka P]]
-
[[Category: Siejka, P]]
+
[[Category: Srikannathasan V]]
-
[[Category: Srikannathasan, V]]
+
[[Category: Tallant C]]
-
[[Category: Tallant, C]]
+
[[Category: Von Delft F]]
-
[[Category: Baf180]]
+
-
[[Category: Brg1-associated factor 180]]
+
-
[[Category: Chromatin remodeling]]
+
-
[[Category: Transcription]]
+

Current revision

Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor

PDB ID 5fbx

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5fbx"
Personal tools