5fd3

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Current revision (06:46, 19 July 2023) (edit) (undo)
 
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<StructureSection load='5fd3' size='340' side='right'caption='[[5fd3]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
<StructureSection load='5fd3' size='340' side='right'caption='[[5fd3]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fd3]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FD3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FD3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fd3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FD3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.42&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fd3 OCA], [http://pdbe.org/5fd3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fd3 RCSB], [http://www.ebi.ac.uk/pdbsum/5fd3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fd3 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fd3 OCA], [https://pdbe.org/5fd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fd3 RCSB], [https://www.ebi.ac.uk/pdbsum/5fd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fd3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LIN54_HUMAN LIN54_HUMAN]] Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner.
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[https://www.uniprot.org/uniprot/LIN54_HUMAN LIN54_HUMAN] Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Felthousen, J G]]
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[[Category: Felthousen JG]]
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[[Category: Goetsch, P D]]
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[[Category: Goetsch PD]]
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[[Category: Lee, H]]
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[[Category: Lee H]]
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[[Category: Litovchick, L]]
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[[Category: Litovchick L]]
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[[Category: Marceau, A H]]
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[[Category: Marceau AH]]
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[[Category: Rubin, S M]]
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[[Category: Rubin SM]]
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[[Category: Strome, S]]
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[[Category: Strome S]]
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[[Category: Tripathi, S M]]
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[[Category: Tripathi SM]]
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[[Category: Tesmin domain]]
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[[Category: Transcription factor]]
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[[Category: Transcription-dna complex]]
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Current revision

Structure of Lin54 tesmin domain bound to DNA

PDB ID 5fd3

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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