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5fg5

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<StructureSection load='5fg5' size='340' side='right'caption='[[5fg5]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='5fg5' size='340' side='right'caption='[[5fg5]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fg5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FG5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FG5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fg5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FG5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5XF:~{N}-(1,3-DIMETHYL-2-OXIDANYLIDENE-6-PYRROLIDIN-1-YL-BENZIMIDAZOL-5-YL)-2-METHOXY-BENZAMIDE'>5XF</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRPF1, BR140 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5XF:~{N}-(1,3-DIMETHYL-2-OXIDANYLIDENE-6-PYRROLIDIN-1-YL-BENZIMIDAZOL-5-YL)-2-METHOXY-BENZAMIDE'>5XF</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fg5 OCA], [http://pdbe.org/5fg5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fg5 RCSB], [http://www.ebi.ac.uk/pdbsum/5fg5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fg5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fg5 OCA], [https://pdbe.org/5fg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fg5 RCSB], [https://www.ebi.ac.uk/pdbsum/5fg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fg5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
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[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
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==See Also==
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*[[Peregrin|Peregrin]]
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Brennan, P E]]
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[[Category: Brennan PE]]
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[[Category: Chaikuad, A]]
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[[Category: Chaikuad A]]
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[[Category: Delft, F von]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M]]
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[[Category: Fedorov O]]
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[[Category: Fedorov, O]]
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[[Category: Filippakopoulos P]]
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[[Category: Filippakopoulos, P]]
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[[Category: Gerstenberger BS]]
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[[Category: Gerstenberger, B S]]
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[[Category: Knapp S]]
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[[Category: Knapp, S]]
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[[Category: Muller S]]
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[[Category: Muller, S]]
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[[Category: Nunez-Alonso G]]
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[[Category: Nunez-Alonso, G]]
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[[Category: Owen DR]]
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[[Category: Owen, D R]]
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[[Category: Savitsky P]]
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[[Category: Savitsky, P]]
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[[Category: Tallant C]]
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[[Category: Tallant, C]]
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[[Category: Von Delft F]]
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[[Category: Moz-morf complex]]
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[[Category: Peregrin]]
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[[Category: Transcription]]
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Revision as of 06:49, 19 July 2023

Crystal structure of the bromodomain of human BRPF1 in complex with PFI-4 chemical probe

PDB ID 5fg5

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