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5fju

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Current revision (06:54, 19 July 2023) (edit) (undo)
 
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<StructureSection load='5fju' size='340' side='right'caption='[[5fju]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
<StructureSection load='5fju' size='340' side='right'caption='[[5fju]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fju]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FJU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FJU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fju]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Amycolatopsis_sp. Amycolatopsis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FJU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CR:N-ACETYL-L-PHENYLALANINE'>5CR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.52&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fjo|5fjo]], [[5fjp|5fjp]], [[5fjr|5fjr]], [[5fjt|5fjt]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CR:N-ACETYL-L-PHENYLALANINE'>5CR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/o-succinylbenzoate_synthase o-succinylbenzoate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.113 4.2.1.113] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fju OCA], [https://pdbe.org/5fju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fju RCSB], [https://www.ebi.ac.uk/pdbsum/5fju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fju ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fju OCA], [http://pdbe.org/5fju PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fju RCSB], [http://www.ebi.ac.uk/pdbsum/5fju PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fju ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NSAR_AMYSP NSAR_AMYSP] Acts as a N-succinylamino acid racemase (NSAR) that catalyzes the racemization of N-succinyl-phenylglycine and N-succinyl-methionine (PubMed:14705949, PubMed:24955846). Can catalyze the racemization of a broad range of N-acylamino acids, including N-acetyl-D/L-methionine, N-propionyl-D/L-methionine, N-butyryl-D/L-methionine and N-chloroacetyl-L-valine (PubMed:7766084, PubMed:10194342, PubMed:14705949, PubMed:23130969). Also converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:10194342, PubMed:14705949, PubMed:24955846). Catalyzes both N-succinylamino acid racemization and OSB synthesis at equivalent rates (PubMed:14705949, PubMed:24955846). NSAR is probably the biological function of this enzyme (Probable).<ref>PMID:10194342</ref> <ref>PMID:14705949</ref> <ref>PMID:23130969</ref> <ref>PMID:24955846</ref> <ref>PMID:7766084</ref> <ref>PMID:16740275</ref> <ref>PMID:24955846</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Amycolatopsis sp]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: O-succinylbenzoate synthase]]
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[[Category: Campopiano D]]
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[[Category: Campopiano, D]]
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[[Category: Grogan G]]
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[[Category: Carron, G Sanchez]]
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[[Category: Sanchez Carron G]]
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[[Category: Grogan, G]]
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[[Category: Isomerase]]
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[[Category: N-acyl amino acid]]
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[[Category: Racemase]]
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Current revision

N-acyl amino acid racemase from Amycolatopsis sp. Ts-1-60: Q26A M50I G291D F323Y mutant in complex with N-acetyl phenylalanine

PDB ID 5fju

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OCA

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